Andreu-Agullo

Ariga

Coumailleau

Ferron

Hanai

J. Wang

Lambert

Ngamukote

Pike

R. K. Yu

Ringerike

Yanagisawa

Significance
          Gangliosides are abundantly expressed in the nervous system and are known to play important roles in neurodevelopment. We previously demonstrated that GD3 is a predominant ganglioside species (&gt;80% of the total gangliosides) in mouse neural stem cells (NSCs). To investigate its biological function, we found that GD3 is colocalized and interacts with the mitogen receptor EGFR in the microdomain structure of the plasma membrane. Such an interaction preserves the EGFR via an endosomal-plasma membrane recycling pathway after endocytosis of EGF and facilitates the EGF-mediated signaling responsible for regulating NSC cell-fate determination. This is an example of how a specific ganglioside can mediate the reuse of a mitogen receptor for promoting efficient cellular proliferation.</jats:p

Jing Wang

Robert K. Yu

Crossref

Proceedings of the National Academy of Sciences

Interaction of ganglioside GD3 with an EGF receptor sustains the self-renewal ability of mouse neural stem cells in vitro

Interaction of ganglioside GD3 with an EGF receptor sustains the self-renewal ability of mouse neural stem cells in vitro

Abstract

Similar works

Full text

Available Versions

Crossref