A QSAR study of 3-(phthalimido alkyl)-pyrazolin-5-ones

Abstract

A group of 17 new 3-(phthalimidoalkyl)-pyrazolin-5-ones were tested for their mitodepressive activity upon the growth of Lepidium sativum L. seeds (Cresson). All of them have shown mitodepressive effect on the growth of the plant. Four topological indices (the Wiener index, the valence-connectivity index, the Balaban index and the information-theoretic index) were used in QSAR studies (inhibition of plant growth in % and cytostatic activity in ED50) on these compounds. We obtained QSAR models that can predict cytostatic activity on the HeLa cells (in ED50) with considerable accuracy