The Role Cytochrome P450 in Aerotoxic Syndrome

Abstract

Aerotoxic syndrome is a set of acute (gastrointestinal, respiratory, irritation) and chronic (mostly neurological) symptoms of rising importance due to the increase in the frequency of air transport use caused by globalization. It represents great danger affecting health of passengers and crew members. It is assumed to be caused by exposure to tricresylphosphate, a compound found in engine oils used in aircrafts. This article presents an overview of in vivo and in vitro research on toxicity of tricresylphosphates