A Dignass

AL Hernandez

APR Costa

DB Young

F Magro

H Khalili

I Monteleone

J Jantsch

J-F Lin

JT Holbrook

KJ Binger

KW Schroeder

M Henriksen

M Kleinewietfeld

MH Giaffer

MS Silverberg

R Yilmaz

S Srivastava

S Vermeire

W Wang

W Wen

Y Fengming

Y Wei

Scientific Reports

AbstractWe evaluated the in-vitro effect of potassium on CD4+ T cells and the role of urinary potassium as a potential biomarker of disease activity in patients with ulcerative colitis (UC). This prospective observational cohort study included healthy controls (n = 18) and UC patients [n = 30, median age: 40 (IQR: 28–46) years, 17 males)] with active disease(assessed by Mayo score) from September 2015–May 2016. Twenty-four hours urinary potassium along with fecal calprotectin (FCP) were estimated in UC patients (at baseline and follow-up after 3–6 months) and controls. In healthy volunteers, we also assessed the effect of potassium on CD4+ T cells differentiated in the presence of Th17 polarizing condition. UC patients had significantly higher FCP (368.2 ± 443.04 vs 12.44 ± 27.51, p &lt; 0.001) and significantly lower urinary potassium (26.6 ± 16.9 vs 46.89 ± 35.91, p = 0.01) levels than controls. At follow-up, a significant increase in urinary potassium among patients who had clinical response [n = 22, 21.4 (14.4–39.7) to 36.5 (20.5–61.6), p = 0.04] and remission [n = 12, 18.7 (9.1–34.3) to 36.5 (23.4–70.5), p = 0.05] was accompanied with a parallel decline in FCP. On in-vitro analysis, potassium under Th17 polarizing conditions significantly inhibited IL-17 and interferon-$$\gamma $$
                      
                        γ
                      
                     expression while favoring the induction of FoxP3+ T cells. Therefore, urinary potassium levels are inversely associated with disease activity in UC with in-vitro data supporting an immune-tolerant role of potassium.</jats:p

Sandeep Goyal

Ritika Rampal

Saurabh Kedia

Sandeep Mahajan

Sawan Bopanna

Devesh P. Yadav

Saransh Jain

Amit Kumar Singh

Md. Nahidul Wari

Govind Makharia

Amit Awasthi

Vineet Ahuja

Crossref

Urinary potassium is a potential biomarker of disease activity in Ulcerative colitis and displays in vitro immunotolerant role

Urinary potassium is a potential biomarker of disease activity in Ulcerative colitis and displays in vitro immunotolerant role

Abstract

Similar works

Full text

Available Versions

Crossref