Alexander Scott

Betty Tyler

Brem

Byron Masi

Chang

Ewend

Fung

Henry Brem

Kevin Spencer

Lee Hwang

Michael Cima

Paek

Pirzkall

Rachel Grossman

Robert Langer

Robert Wicks

Rusciano

Sawyer

Stark

Strasser

Urvashi M. Upadhyay

Yoda Patta

Significance
          Brain metastases represent the most common intracranial tumors in adults. Adequate chemotherapy delivery to the CNS is hindered by the blood–brain barrier. Efforts in intracranial chemotherapy delivery aim to maximize CNS levels while minimizing systemic toxicity; however, the success has been limited thus far. In this work, intracranial implanted doxorubicin and temozolomide microcapsules are compared with systemic administration in a novel rodent model of breast adenocarcinoma brain metastases. These microcapsules are versatile and efficacious, but that efficacy may depend on the ability of the chemotherapy to diffuse in brain tissue. These insights apply to other non-CNS applications of local drug delivery, and drugs should be evaluated based on their ability to penetrate the targeted tissue as well as their inherent efficacy.</jats:p

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Proceedings of the National Academy of Sciences

Intracranial microcapsule chemotherapy delivery for the localized treatment of rodent metastatic breast adenocarcinoma in the brain

Intracranial microcapsule chemotherapy delivery for the localized treatment of rodent metastatic breast adenocarcinoma in the brain

Abstract

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