Ao W

Carlos Cantú-Brito

Elba Reyes

Ethel Garcia Latorre

Fernando Barinagarrementeria

Gabriela Cesarman-Maus

Jorge Sanchez-Guerrero

Katherine A. Hajjar

Rosario Villa


            Background and Purpose—
            Cerebral venous thrombosis (CVT) may be a manifestation of underlying autoimmune disease. Antibodies against annexin A2 (anti-A2Ab) coincide with antiphospholipid syndrome, in which antiphospholipid antibodies (aPLA) are associated with thrombosis in any vascular bed. Annexin A2, a profibrinolytic receptor and binding site for β2-glycoprotein-I, the main target for aPLA, is highly expressed on cerebral endothelium. Here we evaluate the prevalence of anti-A2Ab in CVT.
          
          
            Methods—
            Forty individuals with objectively documented CVT (33 women and 7 men) and 145 healthy controls were prospectively studied for hereditary and acquired prothrombotic risk factors, classical aPLA, and anti-A2Ab.
          
          
            Results—
            
              One or more prothrombotic risk factors were found in 85% of CVT subjects, (pregnancy/puerperium in 57.5%, classical aPLA in 22.5%, and hereditary procoagulant risk factors in 17.5%). Anti-A2Ab (titer &gt;3 SD) were significantly more prevalent in patients with CVT (12.5%) than in healthy individuals (2.1%,
              P
              &lt;0.01, OR, 5.9).
            
          
          
            Conclusions—
            Anti-A2Ab are significantly associated with CVT and may define a subset of individuals with immune-mediated cerebral thrombosis.
          </jats:sec

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Stroke

Autoantibodies Against the Fibrinolytic Receptor, Annexin A2, in Cerebral Venous Thrombosis

Autoantibodies Against the Fibrinolytic Receptor, Annexin A2, in Cerebral Venous Thrombosis

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