A. B. Nielsen

Bancroft JD

Bradshaw J

Bundza A

Dukes TW

H. E. Jensen

Ironside JW

Johnson RC

Kleihues P

Lindner M

Mitcham SA

Monlux AW

P. S. Leifsson

Sartin EA

Sprinkle TJ

Sullivan DJ

 To establish a simple and uniform classification of bovine peripheral nerve sheath tumors (PNSTs), 63 tumors from 44 cattle were examined histologically and immunohistochemically with antibodies against S100 protein and 2′,3′-cyclic nucleotide-3′-phosphohydrolase (CNPase). Immunohistochemically, all the tumors were positive for S100 protein, CNPase, or both. Four types of PNST were recognized: 35 schwannomas, 9 neurofibromas, 14 hybrid (neurofibroma–schwannoma) tumors, and 5 malignant PNSTs. Axons were identified by immunohistochemistry for neurofilament in a proportion of tumors of each type of PNST. In conclusion, bovine PNSTs commonly have both schwannomatous and neurofibromatous areas. Moreover, the Schwann cell markers S100 protein and CNPase, in combination with antibodies against neurofilament, are valuable diagnostic tools to classify bovine PNSTs. </jats:p

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Veterinary Pathology

Immunohistochemistry for 2′,3′-Cyclic Nucleotide-3′-Phosphohydrolase in 63 Bovine Peripheral Nerve Sheath Tumors

Immunohistochemistry for 2′,3′-Cyclic Nucleotide-3′-Phosphohydrolase in 63 Bovine Peripheral Nerve Sheath Tumors

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