This study examined the assessment of cultural influences on entrepreneurial activities of small manufacturing firms in Nigeria. The study adopted the survey method with emphasis on small manufacturing firms in Nnewi. 98 manufacturing firms were sampled. The study results agreed that cultural influences affect SME’s/entrepreneur’s ability to succeed and survive. There is need to emphasis the educational and leadership factors by encouraging the age-long individuality of igbo man. Generally, just as other cited authors have sounded a note of warning, the significance of the relationship between factors of entrepreneurial success and the cultural environment should be applied with caution