Integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras suppressor 1

Abstract

Journal ArticleCell adhesion and migration are dynamic pro- cesses requiring the coordinated action of multiple signaling pathways, but the mechanisms underlying signal integration have remained elusive. Drosophila embryonic dorsal closure (DC) requires both integrin function and c-Jun amino-terminal kinase (JNK) signaling for opposed epithelial sheets to migrate, meet, and suture

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