Identification of a novel pharmacophore for peptide toxins interacting with K+ channels

Abstract

Journal ArticleқM-conotoxin RIIIK blocks TSha1 K+ channels from trout with high affinity by interacting with the ion channel pore. As opposed to many other peptides targeting K+ channels, қM-RIIIK does not possess a functional dyad. In this study we combine thermodynamic mutant cycle analysis and docking calculations to derive the binding mode of қM-conotoxin RIIIK to the TSha1 channel