The features of pathogenetically directed therapy for chronic pelvic pain syndrome in experimental condition

Abstract

Experimental methods for investigation were performed on 120 four-month age white mongrel male rats, by the sacral plexus damage in animals through the ligating the largest nerve of the plexus – sciatic nerve, which can be considered as a predictor of pudendopathy and adequate clinical experimental modeling of the prototype method. The experimental animals after 1 month. of modeling were taken medications with muscle relaxant action of the central and peripheral activity and also neurotrophic effect. Comparative assessment of medicines was performed after 2.5 months. by morphological investigation of the pelvic floor and bladder, as well as biochemical analysis of blood, homogenates of the pelvic floor muscles and bladder, with assessment of the α2-macroglobulin, creatine kinase and lactate activity. The results showed that the pudendal nerve neuropathy in the experiment is accompanied by severe changes in the structure of the tissue of the bladder, pelvic floor muscles, nerve structures of the pelvis, as well as hypoxia, proteolysis and tissue destruction. The injection of drugs to experimental animals with reproduced pudendopathy revealed the different efficacy in restoring the structure of the detrusor muscle and the pelvic floor depending on effect of the drug