Exploration of trans-2-(1,2,3-triazolyl)-cyclohexanols as potential inhibitors for fungal glycosidases

Abstract

A series of carbasugars based on trans-2-(1,2,3-triazolyl)-cyclohexanol moiety was synthesized for the first time by a “click reaction” of the corresponding azides and alkynes, and tested for the inhibitory activity towards fungal glycosidases from Aspergillus and Penicillium sp