EVALUATION OF ANTIOXIDANT, ANTIDIABETIC, AND CYTOTOXIC ACTIVITIES OF THE SECONDARY METABOLITE COMPOUNDS FROM THE THREE PLANTS SPECIES COLLECTED IN TAUNGGYI REGION (MYANMAR)
The present study describes the isolation and structure elucidation of secondary
metabolite compounds from Myanmar medicinal plants. Thirteen known compounds
were identified from the stem bark of Casimiroa edulis, four were discovered for the
first time from this genus. At the same time, three known sesquiterpenes, and a
phenylpropanoid were isolated from the rhizomes of Curcuma comosa and Asparagus
racemosus. Their structures were identified by comparison of experimental and
published spectroscopic data. Some isolated compounds were evaluated for their
antioxidant activity using the DPPH assay. All of them were showed no significant
activity. Compounds KNWT-1 to KNWT-7, KNWT-14, 15, and 16 were evaluated for
their cytotoxicity against HeLa and T47D cell lines. KNWT-2, 7, 15, 16 showed
moderate cytotoxic activity with IC50 value in the ranging from 10.93-77.18 g/mL.
Although all isolated compounds were known, this was the first phytochemical study
from Taunggyi medicinal plants
