The analyses of pigments on important paintings is a delicate issue because it is necessary not to harm the work of art. The use of non invasive techniques becomes mandatory within this restrain. Non invasive spectroscopic techniques together with multispectral imaging is the best way to deal with the issue. Multispectral imaging techniques need to be calibrated as every different CCD camera works in a different way. The analysis of a built experimental oil painted palette using ancient and modern pigments provides intrinsic information for a better comprehension of the artwork’s initial painting, restoration, and current state of conservation and is the better way to calibrate a specific CCD camera. The focus of this paper is given to practical aspects using Multi-analytical and imaging noninvasive techniques, such as Infrared false color, X-Ray Fluorescence (XRF), Fiber Optic Reflectance Spectroscopy (FORS), and Raman spectroscopy. Some case studies will be showed in which the calibrated CDD camera supports the recognition of the painter palette in a non invasive way
