Objective: To analyze HLA-G, Hsp-70, and VCAM-1 proteins
expression on trophoblast in women with preeclampsia and women
with normal pregnancy, and to assess causality relationship between
low HLA-G expression and the increased Hsp-70 and VCAM-1 expression in preeclampsia.
Method: Observational analytic study with cross sectional design.
Results: Trophoblastic HLA-G expression in pregnant women
with preeclampsia is lower (p = 0.01) than its expression in women
with normal pregnancy. The expressions of Hsp-70 (p = 0.02) and
VCAM-1 (p = 0.00) in preeclampsia are higher, compared to normal
pregnancy. Regression analysis showed that low HLA-G is a
predictor for the increase of trophoblastic Hsp-70 and VCAM-1.
Conclusion: Low trophoblastic HLA-G in is a predictor for endothelial
dysfunction in women with preeclampsia.
[Indones J Obstet Gynecol 2010; 34-4: 185-90]
Keywords: preeclampsia, HLA-G, Hsp-70, VCAM-1, endothelial
dysfunctio
