Tranexamic acid in total knee replacement Which protocol? Which application form? :A prospective randomised study

Abstract

The aim of this study was to prospectively compare different doses and application forms of TXA for the reduction of blood loss in patients with TKR and evaluate the results. This study included patients who were unresponsive to conservative management and 168 patients met the inclusion criteria. They were divided into 5 groups randomly as, Control (1), Local (2), Systemic+short infusion (3), Systemic+long infusion (4) and Systemic+oral (5). When compared with the Control group, blood loss was significantly reduced in Groups 2, 3 and 4 (p=0.001,0.001,0.003) but when the TXA protocols were compared, no statistically significant difference was observed. It was determined that in comparison with the control group, all the protocols for the use of TXA reduced blood loss and the need for transfusion without any increase in the complication rate. TXA is considered to be more effective and reliable than systemic use