Design, synthesis and antimicrobial screening of s-Triazinyl piperazine and piperidine derivatives

Abstract

A series of ten 2,4,6-trisubstituted s-triazines have been synthesized selectively with nucleophilic reagents such as 4-amino benzonitrile, 8-hydroxy quinoline and different piperazine as well as piperidine substituents on the C-6 position of s-triazine ring. The title compounds were then examined for their in vitro microbial activity against 2 gram –Ve bacteria (E. Coli, P. Aeruginosa), 2 gram +Ve bacteria (S. Aerues, B. subtilis) and 2 fungal species (C. Albicans and A. niger). The most of the synthesized compounds have shown potent anti-bacterial and anti-fungal activities. Structure of final scaffolds has been affirmed by means of IR, 1H NMR, 13C NMR and elemental analysis.Keywords: 2,4,6-trichloro-1,3,5-triazine, 8-hydroxy quinoline, 4-amino benzonitrile, anti microbial activity