Agerschou, J

Auerbach, P L

Hoejgaard, L

Kjaer, A

Larsen, Mads Rosenkilde

Nielsen, Maria Booth

Ploug, Thorkil

Reichkendler, M H

Sjödin, A

Stallknecht, B

OBJECTIVE: The dose-response effects of exercise training on insulin sensitivity, metabolic risk, and quality of life were examined.METHODS: Sixty-one healthy, sedentary (VO₂max: 35 ± 5 ml/kg/min), moderately overweight (BMI: 27.9 ± 1.8), young (age: 29 ± 6 years) men were randomized to sedentary living (sedentary control group; n = 18), moderate (moderate dose training group [MOD]: 300 kcal/day, n = 21), or high (high dose training group [HIGH]: 600 kcal/day, n = 22) dose physical exercise for 11 weeks.RESULTS: The return rate for post-intervention testing was 82-94% across groups. Weekly exercise amounted to 2,004 ± 24 and 3,774 ± 68 kcal, respectively, in MOD and HIGH. Cardiorespiratory fitness increased (P &lt; 0.001) 18 ± 3% in MOD and 17 ± 3% in HIGH, and fat percentage decreased (P &lt; 0.001) similarly in both exercise groups (MOD: 32 ± 1 to 29 ± 1%; HIGH: 30 ± 1 to 27 ± 1%). Peripheral insulin sensitivity increased (P &lt; 0.01) (MOD: 28 ± 7%; HIGH: 36 ± 8%) and the homeostasis model assessment of insulin resistance decreased (P &lt; 0.05) (MOD: -17 ± 7%; HIGH: -18 ± 10%). The number of subjects meeting the criteria of the metabolic syndrome decreased by 78% in MOD (P &lt; 0.01) and by 80% in HIGH (P &lt; 0.05). General health assessed by questionnaire increased similarly in MOD (P &lt; 0.05) and HIGH (P &lt; 0.01).CONCLUSIONS: Only minor additional health benefits were found when exercising ∼3,800 as opposed to ∼2,000 kcal/week in young moderately overweight men. This finding may have important public health implications.</p

Copenhagen University Research Information System

Only minor additional metabolic health benefits of high as opposed to moderate dose physical exercise in young, moderately overweight men

Only minor additional metabolic health benefits of high as opposed to moderate dose physical exercise in young, moderately overweight men

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