The purpose of the study was to draw upan experimental model of hepatic
veno-occlusive disease (VOD) induced by dactinomycin (ACT) and to investigate
the possible hepatoprotective effects of Ethyol (amifostine). Pathological changes
corresponding to a VOD picture of varying intensification were found in the
liver samples obtained from all the rats receiving ACT. Amifostine appears to act
protectively to liver changes caused by dactinomycin
