research
Extensions in Joint Modeling of Survival and Longitudinal Outcomes
- Publication date
- 24 April 2014
- Publisher
- __abstract__
In many medical studies both longitudinal and event history data are collected
for each patient. A well-known and broadly studied example is found
in AIDS research, where CD4 cell counts taken at different time points are
related to the time-to-death. Often such outcomes are separately analyzed.
However, in two particular settings a joint modeling approach is required.
First, when focus is on the event times and we wish to study the association
between the longitudinal responses and the risk for an event, where we
need to take into account the fact that the longitudinal response is also an
outcome generated by the same subject. Second, when focus is on the longitudinal
outcome and events cause dropout. Under specific circumstances
the dropout process needs to be accounted in the analysis in order to obtain
valid inferences for the longitudinal outcome.