Biological response modifiers are agents that · exert their
antitumor effects mainly or exclusively through modulation of
host immune defense mechanisms. A common feature of these agents
is their capacity to induce the production of endogenous interferons
and/ or other lymphokines in vivo, and their capacity to
activate various subsets of lymphocytes and monocytes that can
lyse tumor cells in vitro and in vivo. Antiproliferative and
immunomodulative effects as well as toxicity and side-effects
observed in connection with the admin