This database contains data collected from a double-blind randomized controlled trial that assessed the impact of route of oxytocin administration on postpartum blood loss and rates of postpartum hemorrhage (PPH) when administered during the third stage of labor following vaginal delivery. Participants who gave birth at a hospital in Argentina were assigned to receive 10 IU oxytocin via intravenous (IV) infusion or intramuscular injection (IM) injection and a matching saline ampoule for the other route . Blood loss was measured using a calibrated receptacle for a 1-hour minimum