AIMS OF THE STUDIES
1. To investigate the diagnostic value of colposcopy under research conditions,
in patients with an indication for colposcopy. (Wouter M. Huisman)
2. To investigate the possibility of accurately predicting histopathology by means
of the colposcopic impression, when a standard set of diagnostic criteria is
used. (Wouter M. Huisman)
3. To investigate the predictive contribution of colposcopy in grading CIN and
in the recognition of human papilloma virus (HPV) infections within the
standard facilities of the University Hospital Dijkzigt-Rotterdam in the routine
cytologic, colposcopic and histopathologic evaluation of selected patients with
cervical smears suggestive of cervical intraepithelial neoplasia. (J.A. Wijnen)
4. To investigate in a prospective randomized study the possible effects of systemic
folic acid supplementation on the cytologic, colposcopic and histopathologic
manifestations of cervical intraepithelial neoplasia. (J.A. Wijnen)
5. To investigate in a prospective randomized study the therapeutic effectiveness
and side-effects of laser- or cryotherapy in patients with cervical intraepithelial
neoplasia. (J.A. Wijnen)