Here the cases of three female patients who received long-term rituximab treatment for seropositive, erosive and deforming rheumatoid arthritis was reported. After rituximab treatment, they presented with recurrent sinusitis and pneumonia, followed by the subsequent development of bronchiectasis. A temporal relationship between rituximab treatment and the onset of respiratory complications was exposed as a possible pathogenic mechanism

Cañas, Carlos A

Santos, Víctor A

Tobón, Gabriel J.

English

Via Medica Journals

PRACA ORYGINALNA310CASE REPORTwww.journals.viamedica.plAddress for correspondence: Gabriel J. Tobón, GIRAT, Fundación Valle del Lili – Universidad Icesi, Cra. 98 18–49, 760026 Cali, Colombia, e-mail: gtobon1@yahoo.comDOI: 10.5603/ARM.a2018.0050Received: 19.10.2018Copyright © 2018 PTChPISSN 2451–4934Víctor A. Santos, Gabriel J. Tobón, Carlos A Cañas GIRAT, Fundación Valle del Lili — Universidad Icesi, Cali, ColombiaDevelopment of bronchiectasis during long-term rituximab treatment for rheumatoid arthritisThe authors declare no financial disclosureAbstractHere are the cases of three female patients who received long-term rituximab treatment for seropositive, erosive and deforming rheumatoid arthritis were reported. After rituximab treatment, they presented with recurrent sinusitis and pneumonia, followed by the subsequent development of bronchiectasis. A temporal relationship between rituximab treatment and the onset of respiratory complications was exposed as a possible pathogenic mechanism.Key words: bronchiectasis, rheumatoid arthritis, rituximab, sinusitisAdv Respir Med. 2018; 86: 310–313IntroductionRituximab is a  chimeric monoclonal an-tibody that targets the transmembrane CD20, which induces the ablation of mature pre-B and B lymphocytes [1]. It was approved by the Food and Drug Administration for the treatment of non-Hodgkin’s lymphoma (1997), rheumatoid ar-thritis (RA) (2006), and positive ANCA vasculitis, such as microscopic polyangiitis and granulo-matosis with polyangiitis (2011) [2]. Other indi-cations for rituximab treatment in autoimmune diseases include systemic lupus erythematosus and inflammatory myopathies [3, 4]. The most relevant adverse events are related to the infusion of rituximab, and less frequently, immunological, respiratory, renal, cardiac and haematological di-sorders as well as the increase of neoplasms and infections. Pulmonary adverse reactions occur in 5.3% of patients undergoing rituximab treat-ment [5], including interstitial lung disease [6], asthma, bronchiolitis obliterans, hypersensitivity pneumonitis, and diffuse alveolar haemorrhage [7–9]. A case of a 17-year-old patient who was receiving 1000 mg of rituximab every 6 months for 6 years for optic neuromyelitis was recently published; the patient developed rhinosinusitis and recurrent pneumonia with the development of bronchiectasis in the context of hypogamaglo-bulinaemia [10].Case reportsIn a cohort of 964 patients with RA treated since 2007 at the Fundación Valle del Lili, a refer-ral care centre in Southwest Colombia, 164 (17%) received biological therapy based on the institu-tional treatment guidelines. Eighty-four patients (8.7%) were given rituximab. The average age at the onset of the disease was 34 (range: 17–60, SD 15). Indications for the initiation of rituximab treat-ment were failure to respond to anti-TNF in 45 (53%) patients, failure to respond to methotrex-ate in 27 (32%) and other reasons in 12 (14%). The average number of rituximab cycles was 4. Each cycle comprised a 1000 mg initial dose and followed with 1000 mg at 2 weeks, indicated for 9 months. There was a lack of therapeutic effec-Víctor A. Santos et al., Development of bronchiectasis during long-term rituximab treatment for rheumatoid arthritis311www.journals.viamedica.pltiveness in six patients (7%). In addition to the de novo development of bronchiectasis, recurrent sinusitis and pneumonias were present in three (3.5%) subjects.Case 1A 76-year-old woman presenting with seropo-sitive, erosive and deforming RA, which initiated at the age of 58, visited our centre with a history of chronic obstructive pulmonary disease (COPD) secondary to smoking manifesting with a chro-nic, productive cough. A chest CT from 2013 is shown in Figure 1A. She received methotrexate, leflunomide, etanercept (2008–2011) and toci-lizumab (2011–2013) treatment with a notable loss of effectiveness. Rituximab was started with a good response in 2013. Two months after the fourth cycle of rituximab, she presented with pansinusitis and multilobar pneumonia, requiring hospital treatment with parenteral antibiotics. Three months after this episode, she developed a lower respiratory infection with residual cough and a progressive increase in expectoration. CT of the thorax was performed (Fig. 1B), which revealed de novo basal cylindrical bronchiecta-sis. Liver and kidney function tests and serum gammaglobulin levels were normal. Because it was suspected that rituximab played a role in the development of this pulmonary disease, it was decided to withdraw rituximab and initiate oral steroids and tofacitinib treatment. The patient required chronic respiratory therapy to control bronchiectasis symptoms.Case 2A 63-year-old woman with occupational ex-posure to volatile solvents, dust and boiler smoke underwent treatment for seropositive, erosive and deforming RA since the age of 48. She presented with additional conditions, including hypothy-roidism and kidney stones, and denied smoking. She presented refractoriness to the treatment of RA with conventional medications (prednisolone, methotrexate and hydroxychloroquine). Ritux-imab was started in 2009. After the fifth cycle of rituximab, she presented with recurrent high and low respiratory infections (three episodes) that required hospital treatments. A chest CT scan from 2013, which is shown in Figure 1C, revealed mild chronic bronchitic changes. Since then, the patient has reported productive and progressive cough, as well as episodes of dyspnoea associ-ated with bronchospasm. Chronic inhalers with steroids, bronchodilators, respiratory therapy and the management of recurrent infections with antibiotic therapy were indicated. A more recent chest CT scan from 2017 showed cylindrical bron-chiectasis in both lower lobes (Fig. 1D), and a CT scan of the paranasal sinuses suggested chronic sinus disease. CBC, liver and kidney functions and serum gammaglobulin levels were normal. RA is currently being managed with tofacitinib and low doses of oral steroids.Case 3A 65-year-old woman presented with se-ropositive, erosive and deforming RA, which initiated at the age of 48. She had a history of exposure to wood smoke and cigarettes. She was treated for several years with prednisolone, meth-otrexate and chloroquine. In 2006, etanercept was indicated for refractory disease. However, she developed drug-induced lupus (DIL) with glomerulonephritis and cutaneous involvement. Subsequently, etanercept was withdrawn, and rit-uximab was initiated for both DIL and RA control [11]. After the sixth cycle of rituximab, she com-plained of headache, rhinorrhoea, cough of pro-gressive intensity, expectoration and dyspnoea. Pansinusitis and the incipient development of bronchiectasis were documented (Fig. 1E). She was hospitalised in 2016 because of worsen-ing symptoms. The chest CT scan on admission is shown in Figure 1f. Klebsiella oxytoca was isolated from orotracheal secretion. Chronic ven-tilator support was necessary, and tracheostomy was performed. Six weeks after admission, the patient died.DiscussionThis study reported the cases of three female patients aged > 60 who received rituximab treat-ment for the control of seropositive RA refractory to conventional and biological treatments. They were given four, five and six cycles of rituximab, respectively (cycles of 1000 mg every 2 weeks every 9 months) before presenting with recurrent sinusitis and pneumonia and subsequently, bron-chiectasis. These three patients had a history of smoking and/or exposure to environmental con-taminants. Sinusitis was confirmed via imaging studies, in addition to changes in haematological tests that are typically indicative of bacterial infection and rising acute phase reactants. They presented with cough with high volumes of spu-tum, which lead to the suspicion of the presence of bronchiectasis, which was confirmed with a chest CT scan. The patients did not show hy-pogammaglobulinaemia.Advances in Respiratory Medicine 2018, vol. 86, no. 6, pages 310–313 312 www.journals.viamedica.plFigure 1. Case 1: A — chest CT from 2013 reported as normal; B — chest CT from 2015 showing cylindrical bronchiectasis in both lung bases. Case 2: C — chest CT from 2013 showing nonspecific bronchial changes; D — chest CT from 2017 showing cylindrical bronchiectasis in both lower lobes. Case 3: E — chest CT from 2014 with incipient bronchiectasis; F — chest CT from 2016 showing the progression of bronchiectasisA BC DE FBronchiectasis is a condition wherein the bronchi and bronchioles dilate as a consequence of the damage to their walls [12], which leads to a  loss of the mucociliary defence mechanisms with consequent colonisation by microorganisms; this in turn causes chronic inflammation and worsening of the tissues that integrate the bronchi and bronchioles [13–18]. Other conditions that may coexist in the same patient, such as foreign body aspiration, gastro-oesophageal reflux, im-mune deficiencies, COPD or conditions similar to RA, have previously been associated with the development of bronchiectasis in adults [19]. Rituximab can affect both cellular and humoral immunity [20]. Several of these conditions were present in the three patients in this report.Pulmonary reactions related to rituximab treatment were reported to have occurred in 5.3% of patients in a previous study [5]. Prolonged treatment with this drug has been announced to be associated with toxicity in the respiratory system, which was named by Bitzan et al. [6] as ‘rituximab (B-cell depleting antibody) associated lung injury (RALI)’. These patients were children who presented with haematological malignancies, configuring a  form of interstitial lung disease with reports of lymphocytic infiltrates in their histopathological samples.The temporal relationship between rituxi-mab treatment and the onset of respiratory com-plications, such as chronic sinusitis, recurrent pneumonia and the subsequent bronchiectasis, in these three patients suggests a pathogenic mecha-nism. Age, the presence of severe RA and chronic exposure to air pollutants may be contributing factors that predispose patients to this phenome-Víctor A. Santos et al., Development of bronchiectasis during long-term rituximab treatment for rheumatoid arthritis313www.journals.viamedica.plnon. Future studies are needed to corroborate this relationship and to make more precise, preventive or therapeutic recommendations for the use or disuse of long-term rituximab treatment for RA.Conflict of interestThe authors declare do conflict of interest.References:1. 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Development of bronchiectasis during long-term rituximab treatment for rheumatoid arthritis

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Development of bronchiectasis during long-term rituximab treatment for rheumatoid arthritis

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