The study sought a correlation between the number of AgNOR granules and
the degree of cervical intraepithelial neoplasia (CIN). Thirty-five sections (5 normal,
10 CIN1, 10 CIN2 and 10 CIN3) were subjected to retrospective analysis.
The percentage of cells with 1, 2, 3, 4 and more AgNORs was calculated and the
number of granules per 100 cells was counted. The number of cells containing
single granules decreases. However, the number increases with CIN level when
the cells contain 4 and more AgNORs. The number of granules per 100 cells also
increases with the degree of CIN. It can be thus concluded that the number of cells
with 4 and more AgNOR granules can serve as a CIN differentiation exponent