The aim of this study was to investigate the influence of two periods of life,
namely P28 and P360, on the changes in interleukin-1beta (IL-1β) immunoreactivity
(-ir) in the hippocampus (CA1, CA3, DG) and amygdala (central-CeA,
medial-MeA) caused by acute and repeated open field (OF), or by forced swim
(FS) exposition. Rats were divided into groups: non-stressed, exposed to acute
(one-time for 15 min) and chronic stressors (21 days for 15 min daily). We
found IL-1β-ir in the control group to be higher in P360 than in P28. In P28,
under OF and FS exposure, IL-1β-ir in the CeA remained unaltered but increased
in the MeA and in the hippocampus after acute and chronic stress. In P360 no
changes were observed in the IL-1β-ir level after acute and chronic stimulation.
These data demonstrate that only the levels of IL-1β-ir in juvenile rat brains are
affected by FS and OF. Additionally, there was no significant difference between
FS and OF stimulation in IL-1β-ir