BACKGROUND: Various radiometal complexes have been developed
for tumour imaging, especially Ga-68 tracer. In this work,
the development of a radiogallium bis(thiosemicarbazone) complex
has been reported.
MATERIAL AND METHODS: [67Ga]acetylacetonate bis(thio-semicarbazone)
complex ([67Ga]AATS) was prepared starting with
[67Ga]Gallium acetate and freshly prepared acetylacetonate
bis(thiosemicarbazone) (AATS) for 30 min at 90ºC. The partition
co-efficient and stability of the tracer was determined in final
solution (25ºC) and the presence of human serum (37ºC) for up
to 24 hours. The biodistribution of the labelled compound in
wild-type and fibrosarcoma-bearing rodents were determined
for up to 72 hours.
RESULTS: The radiolabelled Ga complex was prepared to
a high radiochemical purity (> 97%, HPLC) followed by initial
biodistribution data with the significant tumour accumulation
of the tracer at two hours, which is far higher than free Ga-67 cation, while the compound wash-out is significantly
faster.
CONCLUSION: The above-mentioned pharmacokinetic properties
suggest an interesting radiogallium complex prepared by
the PET Ga radioisotope, 68Ga, in accordance with the physical
half life, for use in fibrosarcoma tumours and possibly in other
malignancies
