Factor VIII:C, epsilon amino-caproic acid or tranexamic acid are prophylactic agents used in
preventing hemorrhage pre-operatively in patients with hemophilia A. Although hemophilia A
seems to be a factor that avoids the development of acute myocardial infarction (AMI) as it
tends to be associated with increased bleeding, it should be kept in mind that prothrombotic
agents used pre-operatively for prophylaxis may increase the risk for AMI in the presence of the
factor V Leiden mutation. In this report, we discuss the development of AMI following the use
of recombinant factor VIII and tranexamic acid for prophylaxis in a patient with known
hemophilia before a tooth extraction in conjunction with the relevant literature