The high quality of a euphonic voice is the result of complex interactions between many organs and
systems. Vibrating vocal folds play a crucial role in this process. Their physiological motion is conditioned by
the presence of the layered structure of laryngeal mucosa. In this study, we assessed the degree of dysphonia
according to the Union of European Phoniatrics (UEP) scale. Videoendoscopy (VLS) and videostroboscopic
(VLSS) examination of the larynx was used to visualize the vibration of the vocal folds. Morphological assessment
of the inter-membranous part of the vocal fold mucosa was carried out using material collected after
surgical treatment (60%) or obtained from autopsy (40%). The samples were examined by light microscopy
and transmission electron microscopy. In euphonic voices, 1° of dysphonia (UEP) and the physiological endoscopic
(VLS) and stroboscopic (VLSS) findings of vocal folds were registered. No morphological or ultramorphological
changes were observed in the cells of the multilayered flat epithelium, basal membrane or in the
stroma. Unchanged epithelial cells were situated on the basal membrane with folds. Moreover, numerous
pericytes, vessels with multiplication of basal membranes, scanty collagenous fibers, plasmatic cells and
lymphocytes were seen. Morphological changes with signs of atrophy and polypoid degeneration of the
vocal fold mucosa were found in only 3 (15%) patients. (Folia Histochemica et Cytobiologica 2011; Vol. 49,
No. 1, pp. 72–79
