Translational medicine is a new paradigm that propitiates the transfer of knowledge built in the experimental laboratory to clinical practice and correlates with the field of Public Health, although there are still challenges. However, several professionals from  different fields  of knowledge, from  researchers  and managers  of health care area  as well as students of the exact sciences, have been conducting research with this focus, from the knowledge generated in the biomedical laboratories or not, correlating to those produced in  basic and applied sciences, focusing on the improvement of health services

Bezerra, Italla Maria Pinheiro

English

Cadernos Espinosanos (E-Journal)

6Translational medicine and  its contribution to public healthJ Hum Growth Dev. 2017; 27(1): 6-9J Hum Growth Dev. 2017; 27(1): 6-9 DOI: http://dx.doi.org/10.7322/jhgd.127642Translational medicine is a new paradigm that pro-pitiates the transfer of knowledge built in the experimental laboratory to clinical practice and correlates with the field of Public Health, although there are still challenges. How-ever, several professionals from  different fields  of knowl-edge, from  researchers  and managers  of health care area as well as students of the exact sciences, have been con-ducting research with this focus, from the knowledge gen-erated in the biomedical laboratories or not, correlating to those produced in  basic and applied sciences, focusing on the improvement of health services.In this frontier of knowledge, Lean et al.1, consid-er translational medicine as a process that leads to evi-dence-based medicine to sustainable solutions to public health problems, providing longevity of populations and improving health service. To do so, it is necessary for scientists to be able, in developing research, to link ba-sic scientific findings with the clinical research area, and to translate the results of clinical trials into transforma-tions in clinical practice through evidence from the social sciences and policies.The idea is to establish the connection between the creation and application of knowledge, integrating re-searchers from the basic and clinical areas to better assist the population. In this perspective, discussions began on Translational medicine and  its contribution to public health Italla Maria Pinheiro Bezerra1,2DOI:  http://dx.doi.org/10.7322/jhgd.127642the importance of clinical research so that it could trans-form knowledge from the basic area, since the develop-ment achieved by clinical research was not adequate to do so at the necessary speed and the efficiency. However, today there is a clear change in the speed and efficiency. Experimental laboratory research and knowledge come to application, having the University  a fundamental role in this change,  because  it  leads the knowledge  to industry, or the industry will seek  the knowledge in the university. Brazil has made a wide development and contri-bution on the field of  Translational Medicine and Pub-lic Health. These contributions maximize health deci-sion-making that is a key factor for maintaining the health of the population, either with disease prevention, as in the case of immunizations, or with health promotion actions, aimed at improving the quality of life of the population affected or not due to health issues. The Journal of Human Growth and Development has been the repository of these discussions and also has contributed to the spread of this knowledge not only in Brazil  but also  around the world, doing  an important effort  with  their publications  in Eng-lish  which is   the language of modern science.However, the challenges to facilitate the cycle of scientific discovery from innovation in health care are still a major concern for individuals and communities seeking 1 Escola Superior de Ciências da Santa Casa de Misericórdia de Vitória, EMESCAM. Vitória, ES. 2	 Laboratório	de	Delineamento	de	Estudos	e	Escrita	Científica	da	Faculdade	de	Medicina	do	ABC,	Santo	André,	SP.	 Corresponding author:	Italla	Maria	Pinheiro	Bezerra	-	E-mail:	italla.bezerra@emescam.brSuggested citation: Bezerra	IMP.	Translational medicine and  its contribution to public health. J Hum Growth Dev. 2017; 27(1): 6-9. Doi: http://dx.doi.org/10.7322/jhgd.127642Manuscript submitted: Oct 16 2016, accepted for publication Nov 14 2016.EDITORIALAbstract: Introduction: Translational medicine is a new paradigm that favors a transfer of knowledge from the lab to the	clinical	practice.	It	correlates	to	the	field	of	Public	Health,	although	there	are	still	challenges.	There	is	a	full	contribution	of	Brazil	in	the	theme	of	Translational	Medicine	and	Public	Health.	These	contributions	to	public	health	maximize	decision	making	in	health,	which	is	fundamental	to	maintain	a	healthy	population.	Objective: Thus,	the	Journal	of	Human	Growth	and	Development	has	been	repository	these	discussions,	contributing	to a dissemination of this knowledge worldwide. Different aspects involving clinical practice and public health are highlighted, discussing the real situation of health conditions in the different contexts. These discussions range from the actions to promote health for the population to investigations that bring results, promoting an improvement in health and contributing to the (re)construction of health actions. The importance of researches investigating	on	means	to	get	the	reengineering	of	the	health	system	is	noted.	It	should	consider	the	needs	medical, researchers, managers and users in order to produce knowledge that will become products to improve the health of population.Keywords: traslational medicine, public health, knowledgeTranslational medicine and  its contribution to public health J Hum Growth Dev. 2017; 27(1): 6-9 7J Hum Growth Dev. 2017; 27(1): 6-9 DOI: http://dx.doi.org/10.7322/jhgd.127642or needing health such as health professionals, decision makers, policy makers and health service funders. The in-terface between building knowledge to identify health im-provement, pure scientific research, clinical study-based research, and finally the implementation of research re-sults into a pragmatic outcome that is a growing source of permanent concern  in clinical research and at community level. Hence, It is a vital investment that has the potential to result in dramatic improvements in overall health out-comes2.For Siminerio and Mbanya3 one of the major chal-lenges of the medical and educational world currently is translational research, in order to reduce the gap between scientific knowledge and effective strategies in health care to improve patient outcomes.Again, this dissemination of knowledge is   includ-ed  in the articles listed in this issue (27.1), that  involves translational medicine and public health.Research focused on growth and human develop-ments4-7 has been highlighted and since its establishment in the 1990s it has been the central theme of this Jour-nal. In the current issue of JHGD these studies evalu-ate technologies that involve the improvement of health conditions and/or issues for public health investigating the health situation of the population, especially chil-dren and adolescents8-10, which corroborate the themes in the health promotion field within the context of pri-mary care focusing on teens and their vulnerabilities11-13, nutrition and influence on child and adolescent develop-ment14-18 and themes focused on translational medicine, describing results to improve the health indicators of the population19-22.With an emphasis on nutritional status, to highlight obesity in adolescents, Tebar et al.17 found the prevalence of abdominal obesity in adolescents in the city of Lon-drina, Paraná, Brazil, and its associated factors. It was evidenced that abdominal obesity showed a significant association with gender and high sedentary behaviour in Brazilian adolescents, independently of other factors.The relation of bone structure and adolescent growth has been illustrated in the investigations about the relation of bone density and the practice of sports in ado-lescents. The basketball practice seems to impact the bone mineral density of adolescents significantly, but highlights the strong effect of variables related to growth and sexual maturation in this process19.In the same context, the physical profile, physi-cal abilities and hormonal markers and the relation with the bone age of this population group were compared. It was evidenced that the physical profile and motor perfor-mance differ according to the gender and maturational stage of children and adolescents, even in a similar age group. Bone age appeared related to motor performance in both the boys and the girls, especially the strength of the upper limbs, which showed a higher correlation with bone age20.Silva et al.21 discussed the relationship between the motor stimulation opportunities in the family environment and children’s motor development of both sexes. The home environment is directly related to the motor devel-opment of girls and boys. Being that the girls come from a home environment with a greater variety of stimulation, materials of fine and gross motricity; and boys residing in households with more fine and gross motor materials presented better levels of motor development.Also in this issue of evaluation of growth and de-velopment, Gomes et al.22 evaluated the pattern of growth and pubertal development of a group of patients with Sickle Cell Anaemia (SCA) from childhood to adulthood. Patients with SCA presented growth impairment and pu-bertal delay when compared to healthy controls. However, although late, they reached normal sexual maturation. In addition, they reached normal height in adulthood, unlike weight and BMI, which is even more evident in males.The JHGD issue 27(1) also contemplates two ar-ticles that deal with postural deviations, aiming to esti-mate the prevalence of postural changes in the vertebral column of Brazilian schoolchildren through a systemat-ic review with meta-analysis, noting that there is a low strength of evidence for establishing a consensus on the values of prevalence of postural deviations in the spine of students23, and the second focused on the analysis of the impact of bronchopulmonary dysplasia (BPD) on lung function of infants and preschool children from zero to 4 years of age24, which indicated that neonates diagnosed early in life in the neonatal period with BPD have limited expiratory flow and reduced CRF when assessed in early childhood compared to term and preterm infants without BPD. Most new-borns, when they reach the age of five, present improvement in pulmonary function parameters, highlighting the direct effect of growth and development, as well as the acquisition of adequate weight for age.Lastly, issue 27(1) makes a contribution in the field of adolescent vulnerability and the issue of abortion pro-vided by law. It describes the situation of sexual violence and vulnerability in adolescence, as well as the clinical consequences of unsafe abortion and reports this expe-rience, as well as sexual violence in situations of social and age vulnerability. It showed an attempted abortion with self-injury, revealing detrimental clinical effects and health problems of adolescents, reiterating the need for current issues in the field of Public Health and the care for the vulnerable population25.Thus, issue 27(1) of the Journal of Human Growth and Development maintains the tradition of approaching the different aspects that involve the clinical practice of caring for people and public health, evidencing the real situation of the health conditions in the different contexts, from actions that seek to promote the health of the popu-lation to investigations that bring results that will improve the health situation of those involved, contributing to the (re)construction of health actions.The importance of researches that can investigate bet-ter ways of achieving the reengineering of the health system is perceived, considering the medical demands of research-ers, managers and patients/users, in order to produce new knowledge and these becoming products that will propitiate improvement of the health of the population, whether with a new diagnosis or new therapeutic treatments, or with actions aimed at promoting the health of the population.8Translational medicine and  its contribution to public healthJ Hum Growth Dev. 2017; 27(1): 6-9J Hum Growth Dev. 2017; 27(1): 6-9 DOI: http://dx.doi.org/10.7322/jhgd.127642 REFERENCES1.   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Efeitos metabólicos do exercício físico na obesidade infantil: uma visão atual. Rev Paul Pediatr. 2015;33(1):122-9. DOI: http://dx.doi.org/10.1016/j.rpped.2014.11.00210.  Moreira GAR, Vieira LJES, Deslandes SF, Pordeus MAJ, Gama IS, Brilhante AVM. Fatores associados à notificação de maus-tratos em crianças e adolescentes na atenção básica. Ciênc Saúde Coletiva, 2014; 19(10):4267-76. DOI: http://dx.doi.org/10.1590/1413-812320141910.1705201311.  Silva MF, Fontinele DRS, Oliveira AVS, Bezerra, MAR, Rocha SS. Determining factors of domestic accidents in early childhood.  J Hum Growth Dev. 2017;27(1):11-19. DOI: http://dx.doi.org/10.7322/jhgd.127643 12.  Zequinão MA, Cardoso AA, Silva JL, Medeiros P, Silva MAI, Pereira B, et al. School performance and bullying in socially vulnerable students. J Hum Growth Dev. 2017;27(1):20-26. DOI: http://dx.doi.org/10.7322/jhgd.127645 13. Coutinho BLM, Feitosa AA, Diniz CBC, Ramos JLS, Ribeiro LZ, et al. Alcohol And Drugs In Adolescence: Work Process In Health In School Program. J Hum Growth Dev. 2017;27(1):27-33. DOI: http://dx.doi.org/10.7322/jhgd.127646 14.  Freitas AG, Lima DG, Bortolini MJS, Meneguetti DUO, Santos EFS, Silva RPM. Comparison of the nutritional status in children aged fi ve to ten years old of the Conditional Cash Transfer Program in the States of Acre and Rio Grande do Sul, Brazil. J Hum Growth Dev. 2017;27(1):34-40. DOI: http://dx.doi.org/10.7322/jhgd.127647 15.  Silva JP, Silva VR, Almeida PCD, Pinasco GC, Bernardes TP, Sasso JGRJ, et al. Growth and Nutritional Status Of Teens From Public State Education Network. J Hum Growth Dev. 2017;27(1):41-47. DOI: http://dx.doi.org/10.7322/jhgd.127651 16.  Araujo DM, Rovere NC, Lima MCMP. Development of infants with hearing impairment risk indicators and the en-vironment classifi cation. J Hum Growth Dev. 2017;27(1):48-54. DOI: http://dx.doi.org/10.7322/jhgd.127652 17.  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DOI: http://dx.doi.org/10.7322/jhgd.127655 Therefore, even greater investment becomes necessary in financial terms and for personnel who can contribute to the development of innovative ap-proaches, accelerating the transfer of knowledge, as well as encouraging the formation of interdisciplinary researchers who can establish network partnershipsand exchanges, that are necessary for the development of translational medicine and public health contributions. researchers who can establish network partnerships and exchanges, that are necessary for the development of translational medicine and public health contributions.Translational medicine and  its contribution to public health J Hum Growth Dev. 2017; 27(1): 6-9 9J Hum Growth Dev. 2017; 27(1): 6-9 DOI: http://dx.doi.org/10.7322/jhgd.12764220.  Pinto VCM, Santos PGMD, Dantas MP, Araújo JPF, Cabral SAT, Cabral BGAT. Relationship Of Skeletal Age And Hormone Markers With Physical Capabilities Of Children And Adolescents. J Hum Growth Dev. 2017;27(1):76-82. DOI: http://dx.doi.org/10.7322/jhgd.127658 21.  Silva WR, Lisboa T, Freitas KD, Ferrari EP, Cardoso FL, Motta NF, et al. Opportunities for motor stimulation in the home environment of children. J Hum Growth Dev. 2017;27(1):83-89. DOI: http://dx.doi.org/10.7322/jhgd.127659 22.  Gomes IGP, Melo HN, Melo SIA, Vasconselos-de-Menezes N, Dantas TVP, Cipolotti R. Growth and Puberty In A Prospective Cohort Of Patients With Sickle Cell Anaemia: An Assessment Over Ten Years. J Hum Growth Dev. 2017;27(1):90-97. DOI: http://dx.doi.org/10.7322/jhgd.127681 23.  Kasten AP, Rosa BN, Schmit EFD, Noll M, Candotti CT. Prevalence of postural changes in the spine in school-children: a systematic review with meta-analysis. J Hum Growth Dev. 2017;27(1):98-107. DOI: http://dx.doi.org/10.7322/jhgd.12768424. Scalco JC, Coelho R, Mucha FC, Schivinski CIS. Impact Of Bronchopulmonary Dysplasia On Pulmonary Function During Childhood: A Systematic Review. J Hum Growth Dev. 2017;27(1):108-114. DOI: http://dx.doi.org/10.7322/jhgd.127685 25.  Silva ATM, Sousa GD, Lohmann CM, Ferreira Filho ES, Pinheiro WS, Soares Junior JM, et al. Vulnerability in Ado-lescence: A Case Report of Attempted Abortion and Sexual Violence. J Hum Growth Dev. 2017;27(1):115-122. DOI: http://dx.doi.org/10.7322/jhgd.127686 

Translational medicine and its contribution to public health

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Translational medicine and its contribution to public health

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