BONETTI, Franco Claudio

Revista do Instituto de Medicina Tropical de São Paulo

English

Cadernos Espinosanos (E-Journal)

			 	!!*This thesis is available at the Library of the Instituto de Medicina Tropical de São PauloSUMMARY OF THESIS*BONETTI, Franco Claudio – Ação da radiação ionizante sobre a morfologia, fisiologia e crescimento da Leishmania amazonensis, com avaliaçãode seu poder imunogênico em modelos experimentais. São Paulo, 2002. (Dissertação de Mestrado – Instituto de Pesquisas Energéticas eNucleares – Autarquia associada à Universidade de São Paulo).THE ACTION OF IONIZING RADIATION ON THE MORPHOLOGY, PHYSIOLOGY AND GROWTH OFLeishmania amazonensis, WITH AVALIATION OF THEIR IMMUNOGENIC POWER INEXPERIMENTAL MODELSLeishmaniasis is a disease which affects thousands of people in theTropical regions around the world, is caused by a protozoan of the genusLeishmania spp., with urban and wild mammals acting as reservoirs. Inthe mammal host, the amastigote form of the parasite infects andmultiplies into macrophages. Treatments for leishmaniasis have a highcost and are long lasting, frequently resulting in therapy interruption.This procedure culminates with a selection of resistant parasite strains,inducing tolerance to the therapy. Either the control of vectors or themammal host are difficult due the social and economic implications.Thus, the search for alternatives treatments against these protozoans havebeen stimulated. The gamma radiation (60Co) shown to be an efficienttool to kill these parasites maintaining their immunogenicity. Cellularviability, Electronically microscopy and Multiplex-PCR techniquesshowed that, after irradiation, the parasites had their growth inhibited bycytoplasmatic and nucleic material disorganization, appointing thegamma radiation as important in terms of immunogens improvement.Franco Claudio BonettiLaboratório de ProtozoologiaInstituto de Medicina Tropical de S. PauloAv. Dr. Enéas de Carvalho Aguiar 47005403-000 São Paulo – SP – Brasilfrancobonetti@hotmail.com

The action of ionizing radiation on the morphology, physiology and growth of Leishmania amazonensis, with avaliation of their immunogenic power in experimental models

https://www.revistas.usp.br/rimtsp/article/download/30648/32532

Ação da radiação ionizante sobre a morfologia, fisiologia e crescimento da Leishmania amazonensis, com avaliação de seu poder imunogênico em modelos experimentais

Ação da radiação ionizante sobre a morfologia, fisiologia e crescimento da Leishmania amazonensis, com avaliação de seu poder imunogênico em modelos experimentais

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Cadernos Espinosanos (E-Journal)