Ant colony optimization (ACO) algorithms can be used to solve nondeterministic polynomial hard problems. Exploration and exploitation are the main mechanisms in controlling search within the ACO. Reactive search is an alternative technique to maintain the dynamism of the mechanics. However, ACO-based reactive search technique has three (3) problems. First, the memory model to record previous search regions did not completely transfer the neighborhood structures to the next iteration which leads to arbitrary restart and premature local search. Secondly, the exploration indicator is not robust due to the difference of magnitudes in distance matrices for the current population. Thirdly, the parameter control techniques that utilize exploration indicators in their feedback process do not consider the problem of indicator robustness. A reactive ant colony optimization (RACO) algorithm has been proposed to overcome the limitations of the reactive search. RACO consists of three main components. The first component is a reactive max-min ant system algorithm for recording the neighborhood structures. The second component is a statistical machine learning mechanism named ACOustic to produce a robust exploration indicator. The third component is the ACO-based adaptive parameter selection algorithm to solve the parameterization problem which relies on quality, exploration and unified criteria in assigning rewards to promising parameters. The performance of RACO is evaluated on traveling salesman and quadratic assignment problems and compared with eight metaheuristics techniques in terms of success rate, Wilcoxon signed-rank, Chi-square and relative percentage deviation. Experimental results showed that the performance of RACO is superior than the eight (8) metaheuristics techniques which confirmed that RACO can be used as a new direction for solving optimization problems. RACO can be used in providing a dynamic exploration and exploitation mechanism, setting a parameter value which allows an efficient search, describing the amount of exploration an ACO algorithm performs and detecting stagnation situations
