Many peptides released from animal or plant proteins in vitro or in vivo have therapeutic functions in humans beyond bioactivity and adequate nutrition. Different health effects have been attributed to foodborne peptides, including antimicrobial properties, blood pressure lowering (ACE inhibitor) effects, cholesterol lowering ability, antithrombotic and antioxidant activities, increased mineral absorption, immunomodulatory effects and opioid activities. For this reason, nutritional counseling practices deal with these issues. Specific protein fractions with therapeutic effects on body function and health are termed biological peptides and have been shown to have a direct positive effect on health. Angiotensin I-converting enzyme (ACE) is a carboxy-dipeptidyl metallopeptidase associated with the renin angiotensin system that regulates the production of angiotensin II from vasoconstrictor angiotensin-II and peripheral blood pressure that catalyzes the inactivation of vasodilator bradykinin. For this reason, the ACE inhibitor substance in the diet may inhibit hypertension by inhibiting the renin-angiotensin system. Milk proteins are now the main source of bioactive peptides. Such peptides are seen as natural and non-effective alternatives to drugs in the treatment of hypertension. The natural consumption of biological peptides will not be expected to cause side effects of synthetically produced drugs used to control hypertension. Therefore, it can be used as a powerful functional food additive and the ACE inhibitor is a natural and healthy alternative to drugs
