The Mekong Delta is an important economic area, located in the southern part of Vietnam. The Mekong Delta has many potential and opportunities for development, but also new challenges in the context of global climate change, sea level rise, as well as the consequences of blocking the river and the Mekong countries also need to increase competition in international integration. In addition to these challenges, the region also has new opportunities when implementing economic restructuring in line with the policy of restructuring the economy in new conditions, including the establishment of special economic zones as PhuQuoc Resort. Besides analysis based on modern economic theory, this paper uses the input-output framework (I/O Inter-sect oral Scope Model) updated in 2016 for two areas: by the Mekong River and the Rest of Vietnam (ROV) to find inter-regional impacts and to calculate some impact assessments of climate change. The study also analyzes some other factors related to the viewpoint of sustainable regional development in new conditions, income distribution and social security
