This study aims to determine the effectiveness of using effective microorganism as a supplement in diet on growth performance and hepatosomatic index of quails. A 14 days age were used in a trial in triplicate was carried out by compared the control (c) group with three group of effective microbe in which ration was 1L EM:250 L H2O (treatment 1), 1L EM:550 L H2O (treatment 2) and 1L EM:750 L H2O (treatment 3), respectively. The effective microorganism was supplemented via drinking water. Sampling of weight were done every 7 days and growth performance parameter that were used to compare the growth performance of the quails such as Body Weight Gain (BWG), Feed Intake (FI), Feed Conversion Ratio (FCR), Average Daily Gain (ADG) and Hepatosomatic Index (HSI) were recorded. The data collected was analyzed using Statistical Package for Social Science (SPSS). The result shows there was significant different (p<0.05) between control group and three other treatment during week four in terms BWG, FCR, ADG and FI. The result of hepatosomatic index shows no significant different (p>0.05) between treatments as it indicate that the quails supplemented with different ratio of effective microbe had no adverse effect on their liver metabolism. Further study can be done by supplemented the effective microorganism via feed
