In the quest for the etiology of the delayed union of fractures: the inhibitory role of non-steroidal anti-inflammatory drugs - a complex pharmacological phenomenon?
Failure of fracture healing is one of the problems that clinical orthopaedics face in practice. This review will examine the role of non-steroidal anti-inflammatory drugs in fracture healing. It is believed that they are inhibitors of the early stages of fracture healing process, according to experimental models. Clinical studies in this area are few in number and without clear evidence regarding the inhibitory effect of non-steroidal anti-inflammatory drugs. Surprisingly the new substances of this class of drugs (COX-2 inhibitors) have the same action in fracture healing. Despite the possible adverse effects of non-steroidal anti-inflammatory drugs in gastrointestinal, cardiovascular systems and fracture healing, they are widely used for post-surgery orthopaedic pain and inflammation
