Let (R,∗) be a 2-torsion free ∗-prime ring with involution ∗, L= 0 be a nonzero square closed ∗-Lie ideal of R and Z the center of R. An additive mapping F: R −→ R is called a generalized derivation on R if there exists a derivation d: R−→Rcommutes with ∗ such that F(xy) = F(x)y +xd(y) holds for all x,y ∈ R. In the present paper, we shall show that L is contained in the center of R such that R admits a generalized derivations F and G with associated derivations d and g commute with ∗ satisfying several conditions
