Development of roale genn cells (spermatogenesis) takes place in the
testicular seminiferous tubules. The honrones follicle-stimulating honnone
(FSH) and testosterone are essential for the initiation and maintenance of
spermatogenesis.
n>e genn cells in the tubules (spermatogonia, spermatocytes and
spermatids; in order of development) are in intimate contact with the
Sertoli cells which are attached to a basal lamina. Adjacent Sertoli cells
are connected through tight junctions, thus foming a sertoli cell barrier.
The barrier divides the tubules in a basal and an adlum:inal c:anparbnent.
Gem cells enter the adluminal compartment when they have reached a certain
stage of development, and are thereafter not in direct contact with the
environment outside the tubules. Consequently, Sertoli cell secretion
products are thought to play an :inportant role during spermatogenesis.
sertoli cells contain FSH and testosterone receptors 1 and are target
cells for these homones. The germ cells, however, do not contain receptors
for FSH and testosterone. Honnonal control of spermatogenesis therefore
involves effects of hormones on Sertoli cells. However, the peritubular
cells, surrounding the tubules, may also take part in this hormonal
regulation
