Cochran, Todd G.

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University of Montana

University of Montana ScholarWorks at University of Montana Syllabi Course Syllabi Fall 9-1-2001 PHAR 432.01: Biopharmaceutics and Pharmacokinetics Todd G. Cochran University of Montana - Missoula Follow this and additional works at: https://scholarworks.umt.edu/syllabi Let us know how access to this document benefits you. Recommended Citation Cochran, Todd G., "PHAR 432.01: Biopharmaceutics and Pharmacokinetics" (2001). Syllabi. 6218. https://scholarworks.umt.edu/syllabi/6218 This Syllabus is brought to you for free and open access by the Course Syllabi at ScholarWorks at University of Montana. It has been accepted for inclusion in Syllabi by an authorized administrator of ScholarWorks at University of Montana. For more information, please contact scholarworks@mso.umt.edu.     Biopharmaceutics and Pharmacokinetics Pharmacy 432         Todd Cochran  Fall 2001          SB242 3 credits         W: 243-4941; H: 728-2925           tcochran@selway.umt.edu  Class  T,Th  10:10-11:00 am SB 117 Conference M,T, or Th 1:10-3:00  SB 113 Exams     Four Fridays  1:10-3:30 pm  SB 114 Format  28 classes, 11 conferences, 4 exams, final exam  Course Description:  Biopharmaceutics and Pharmacokinetics Biopharmaceutics: Drug absorption, bioavailability, and drug product selection Pharmacokinetics: The rates of drug absorption, distribution, metabolism, and excretion  Course Goals:  The goals of this course are to provide the student with: 1.  An understanding of the fundamental concepts of pharmacokinetics in humans 2.  Skills in the application of pharmacokinetics in dosage regimen design and therapeutic drug monitoring 3.  Knowledge about the application of biopharmaceutics in drug product use and selection  Course Objective: At the end of this course you will be able to design and adjust a patient’s drug dosage regimen to keep the plasma/serum concentration of the drug within a desired therapeutic range.  Along the way, you will gain an understanding of the principles of the ADME of a drug, and how these apply to the optimum utilization of a drug in a patient.  The course is designed for you to gain the knowledge and skills to apply biopharmaceutics and pharmacokinetics principles in pharmaceutical care.  Required Materials: 1. Faculty Pacs: Lecture Notes on Pharmacokinetics; Biopharmaceutics  2. A calculator with natural log (ln) and exponent (e) functions 3. Approximately 30 sheets of 2 or 3 cycle semilog graph paper (photocopy OK) 4. Approximately 10 sheets of linear graph paper 5. Straight edge           FacPac Study  Course Outline:    Pages  Problems Class  Conf  Pharmacokinetics Review of zero and first order kinetics Sep 4  Sep 10,11,13 1-12   Kinetics 1-6 Introduction to Pharmacokinetics  Sep 6    13-15, 111  Intravenous Bolus Injection   Sep 12 # Sep 17,18,20 16-18     # Kinetics (432) will meet Wed 9/12 @ 9:10 in SB117.  Therapeutics (451) will meet Tue Sept 11 @ 10:10 in SB117 Intravenous Infusion    Sep 13  Sep 24,25,27 19-24, 112  Loading Dose, Clearance   Sep 18    25-29, 113   Dosage Regimen Adjustment   Sep 18    30-32, 108-110  Exam 1  Fri Sep 28  1:10-3:30 pm        1-18  Cytochrome P450 enzymes   Sep 20   Oral Administration    Sep 25,27 Oct 1,2,4 33-39, 114  Multicompartment Models   Oct 2  Oct 8,9,11 40-45, 115-117 Method of Residuals     Oct 4   Oct 15,16,18 46-51 Repetitive Drug Administration  Oct 9    52-53 Exam 2  Fri Oct 19  1:10-3:30 pm (Thurs Oct 18  6:30-9:00 pm for ASP trippers)  19-31B  Repetitive IV Dosing    Oct 11,16,18 Oct 22,23,25 54-64   Repetitive Oral Dosing, Loading Dose Oct 23    65-70 Repetitive IV Infusion    Oct 25           Oct 29,30,1 71-82 Dosage Regimen Design & Adjustment Oct 30  Nov 5,6,8 83-87, 118 Exam 3  Fri Nov 9  1:10-3:30 pm        31C-57        Class  Conf  FacPac Probs  Creatinine Clearance    Nov 1     88, 119  Dosage Adjustment in Renal Disease Nov 6,8 Nov 26,27,29  89-95  Nonlinear Pharmacokinetics   Nov 13    96-100  Salt Factor     Nov 13    101 Clearance Concepts: Physiologic Models Nov 15    102-106 Bayesian Pharmacokinetics   Nov 15 Exam 4  Fri Nov 30  1:10-3:30 pm      120-123 58-72  Biopharmaceutics  Pharmacokinetics of Drug Interactions Nov 27  Dec 3,4,6 p-Glycoprotein     Nov 29  Factors Affecting Drug Absorption  Dec 4, 6  Bioavailability and Bioequivalence  Dec 11  Drug Product Selection; Course Eval  Dec 13  Final Exam Monday Dec 17, 8:00-10:00 am   Grading: Four mid-semester exams @ 50 points 200  points 80% Final exam (not cumulative)     50  points 20% Total:      250  points    Bonus points: The four mid-semester exams will have 5 bonus points on each exam. Bonus point questions will be taken from literature articles distributed before each exam.  Approximate grading scale: A = 90%,  B = 80%,  C = 70%,  D = 65%  Course Policies: Students are expected to take all exams at the scheduled time. If you cannot take an exam at the scheduled time, you must contact Todd Cochran or leave a message with a pharmacy secretary (Erika Claxton @ 4621 or Beverly Brooks @ 4765) no later than noon of the day of the exam.  Exams normally must be made up within three class days.  If you have questions regarding the grading of your exam, please make an appointment with Todd Cochran to review your exam.  Appointments must be scheduled within 10 days following the return of your exam.  After that time, adjustment of grades will not be made.  You are encouraged to review the posted exam key before your appointment.  Online Materials: Course handouts that are Word documents will be placed on the School's server at:    Network Neighborhood, Skaggs-03, PharmSci, P2, 432    These files can be accessed and printed in the School's Computer Lab.  Help Sessions:  Wednesdays at 2:10 pm, SB114: Sept 26, Oct 17, Nov 7, Nov 28  Days off:  The following classes will not be held in lieu of the four Friday exams. Class:   Tues Nov 20    Conference: Weeks of Sept 3, Nov 12, Nov 19, Dec 10  Office Hours:  W 2-5 pm; Other hours by appointment.  

PHAR 432.01: Biopharmaceutics and Pharmacokinetics

University of Montana ScholarWorks at University of Montana Syllabi Course Syllabi Fall 9-1-2000 PHAR 432.01: Biopharmaceutics and Pharmacokinetics Todd G. Cochran University of Montana - Missoula Follow this and additional works at: https://scholarworks.umt.edu/syllabi Let us know how access to this document benefits you. Recommended Citation Cochran, Todd G., "PHAR 432.01: Biopharmaceutics and Pharmacokinetics" (2000). Syllabi. 5288. https://scholarworks.umt.edu/syllabi/5288 This Syllabus is brought to you for free and open access by the Course Syllabi at ScholarWorks at University of Montana. It has been accepted for inclusion in Syllabi by an authorized administrator of ScholarWorks at University of Montana. For more information, please contact scholarworks@mso.umt.edu. Course Outline: Class Conference Fac Pac StudvPharmacokineticsT,Th Tuesday Pages ProblemsReview of zero and first order kineticsOne Compartment ModelSep 5Sep 7Sep 5Sep 121-1314 19,-  771-6Intravenous Drug Administration Sep 13# Sep 19 20-24, 78Loading Dose, Clearance Sep 14 25-26, 79 81-Dosage Regimen Adjustment Sep 19 27-28, 82-84Exam 1 TuesSep26 1:10-3:30 pm 1-18Cytochrome P450 enzymes Sept 21Extravascular Administration Sep 26,28 Oct 3 29-35, 85Multicompartment Models Oct 3,5 36-40, 86-89Method of Residuals Oct 10 Oct 10 90-95Exam 2 TuesOct17 1:10-3:30 pm 19 28-Repetitive Drug Administration; IV Dosing Oct 12,17,19 Oct 24 41-50, 99-98Repetitive Oral Dosing, Loading Dose Oct 24 51-55, 99-100Repetitive IV Infusion Oct 26 Oct 31 56-59, 101-106Dosage Regimen Design & Adjustment Oct 31 60-64Exam 3 Tues Nov 14 1:10-3:30 pm 29 57-Creatinine Clearance Nov 2 65Dosage Adjustment in Renal Disease Nov 7* Nov 7* 66-70, 107 109-Nonlinear Pharmacokinetics Nov 9 Nov 28 71-72, 110 112-Clearance Concepts: Physiologic Models Nov 14 114 118-Bayesian Methods Nov 16Exam 4 Tues Dec 5 1:10-3:30 pm 113, 119-122 58-72# Class will meet Wed Sept 13 @ 9:10 in CP204. Phar451 will meet Tue Sept 12 @ 9:40 in SB117* Class and Conference will meet Tuesday Nov 7 (Election Day) in lieu of Tuesday Nov 21.Biopharmaceutics and PharmacokineticPharmacy 432 Fall 2000 3 creditsTodd Cochran SB242 W: 243-4941; H: 728-2 925 tcochran@selway.umt.eduClass T,Th 9:40-10:30 am SB 117Conference Tue. 1:10, or 2:10, or 3:10 SB 336Exams Four Tuesdays 1:10-3 :30 pm SB 117Course Description: Biopharmaceutics and PharmacokineticsBiopharmaceutics: Drug absorption, bioavailabiiity, and drug product selectionPharmacokinetics: The rates of drug absorption, distribution and eliminationCourse Goals: The goals of this course are to provide the student with:1. an understanding of the fundamental concepts of pharmacokinetics in humans2. skills in the application of pharmacokinetics in dosage regimen design andthe rapeutic drug monitoring3. knowledge about the application of biopharmaceutics in drugpro duct use and selectionRequired Materials:1. Faculty Pac: Lecture notes on pharmacokinetics2. Faculty Pac: Biopharmaceutics3. A calculator with natural log (In) and exponent (e) functions4. Approximately 30 sheets of 2 or 3 cycle semilog graph paper5. Approximately 10 sheets of linear graph paper6. Straight edgeCourse Format: 28 classes, 10 conferences, 4 exams, final examBiopharmaceutics and Clinical PharmacokineticsClass rr.Th) Conf. Factors Affecting Drug Absorption Nov 28, 30 p-Glycoprotein Dec 5 Pharmacokinetic Basis of Drug Interactions Dec 7Bioavailability and Bioequivalence Dec 12 Dec 12 Drug Product Selection; Course Evaluation Dec 14Final Exam Tuesday Dec 19, 8:00-10:00 am mGrading:Four mid-semester exams @ 50 points 200 points 80%Final exam (not cumulative) 50 points 20%Total: 250 pointsBonus points: The four mid-semester exams will have 5 bonus points on each exam.Bonus point questions will be taken from a literature article distributed before each exam.Approximate grading scale: A = 90%, B = 80%, C = 70%, D = 65%Course Policies:Students are expected to take all exams at the scheduled time. If you cannot take an exam at the scheduled time, you must contact ToddCochran or leave a message with a pharmacy secretary (Erika Claxton @ 4621 or Beverly Owens @ 4765) no later than noon of the day of the exam. Exams normally must be made up within three class days.If you have questions regarding the grading of your exam, please make an appointment with Todd Cochran to review your exam. Appointments must be scheduled within 10 days following the return of your exam. After that time, adjustment of grades will not be made. You are encouraged to review the posted exam key before your appointment.OnLine Materials: Course handouts that are Word documents will be placed on the School's server at:Network Neighborhood, Skaggs-03, PharmSci, P2, 432These files can be accessed and printed in the School's Computer Lab.Help Sessions: Mon; Sept 25, Oct 16, Nov 13, Dec 4; 3 or 4 pmOffice Hours: M,W,F 1-2 pm; Other hours by appointment.

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PHAR 432.01: Biopharmaceutics and Pharmacokinetics

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