Rosenzweig, Frank

English

University of Montana

University of Montana ScholarWorks at University of Montana Syllabi Course Syllabi 1-2015 BIOB 375.01: General Genetics Frank Rosenzweig University of Montana - Missoula, frank.rosenzweig@mso.umt.edu Follow this and additional works at: https://scholarworks.umt.edu/syllabi Let us know how access to this document benefits you. Recommended Citation Rosenzweig, Frank, "BIOB 375.01: General Genetics" (2015). Syllabi. 3336. https://scholarworks.umt.edu/syllabi/3336 This Syllabus is brought to you for free and open access by the Course Syllabi at ScholarWorks at University of Montana. It has been accepted for inclusion in Syllabi by an authorized administrator of ScholarWorks at University of Montana. For more information, please contact scholarworks@mso.umt.edu.                                                                                                                                                                                                                            GENERAL GENETICS  Biology 375INSTRUCTOR: Prof. Frank Rosenzweigfrank.rosenzweig@umontana.eduHSB416, 243-4834Office hours: MWF 3:10-4Spring 2015http://rosenzweig.dbs.umt.edu/GRAD ASST: Ms. Amy Gallagheramy.gallagher@umontana.eduHSB302Office hours: MWF 10:10 – 11:00http://www.cas.umt.edu/dbs/labs/miller/LECTURES: MWF, 09h10 – 10h00. Forestry 206TEXTBOOKS:	 Genetics: A Conceptual Approach by Benjamin A. Pierce, 5th Edition.W.H. Freeman and Company [ISBN: 978-1-46410-946-1]RESOURCES: 	 The publisher provides on-line resources for students who purchase the 5th Edition. Follow the instructions in the course material bundle.WEB PAGE: 	 Additional reading assignments will be provided as PDF documentsposted on the class Moodle page (e.g., https://umponline.mrooms3.net ) and/or electronically distributed to students’ University e-mail accounts.INTRODUCTION: BIOB375.01 (CRN33402) is 3 credit-hour class that will focus on themolecular genetics of eukaryotes, with special emphasis on transmission genetics, gene structureand gene regulation. Our course will have two major components. First, students will acquiremechanistic understanding of particular genetic phenomena (e.g., DNA replication and repair, gene silencing, cis- and trans-regulation), and in the process, gain knowledge about experimentaltools used to acquire that understanding. Second, students will learn how these tools and thisunderstanding are being used to address questions on the leading edge of development, behavior, microbiology, neuroscience, evolutionary and cellular biology. To give but a couple ofexamples: gene copy number can influence cancerous cells and susceptibility to HIV infection; also, gene imprinting strongly influences brain and behavioral development in many mammals.EXPECTED OUTCOMES: Biology 375 will emphasize biological principles, scientificconcepts, and experimental design. Expected outcomes are that you will thoroughly understandthe mechanisms of inheritance, develop a firm grasp on fundamental principles of gene structure, gene expression and gain experience in reading primary literature that uses genetics to addressfundamental biological questions. Genetics is a problem-based science. Problem sets, essays, and exams will be designed to encourage students to synthesize subject matter, not simply to test their ability to recall details.   1                                    MISCELLANEOUS INFORMATION                                                                                                                                                                                                                                                  LECTURES: Attendance at lectures is an important part of this course, and all students areexpected to attend lectures regularly. Videos or animations may be presented, and examplesfeatured in these videos may be used as a basis for exam questions.REVIEW SESSIONS: Optional review sessions will be held at least 2 days prior to each examat a time and location to be established in class. Prerequisites BIOB375 is one of two required cores in the newly approved Genetics and Evolution Option. To be registered in BIOB375 students must have successfully completed theIntroductory Biology sequence (BIOB160 and BIOB171), and Genetics and Evolution (BIOB272). Transfer students’ coursework in these areas is subject to review by the Biology Advisor, Dr. Kerry Bright (Biology.Advisor@mso.umt.edu )Accommodations to ensure accessibility of students with disabilities will be gladly made. In order to qualify a student must be registered with Disability Services for Students (DSS). Arrangements for accommodations on exams will be made through DSS.Academic misconduct will be reported and handled as described in the UM Student ConductCode. All students must practice academic honesty. Academic misconduct is subject to an academic penalty by the course instructor and/or a disciplinary sanction by the University. Allstudents need to be familiar with the Student Conduct Code. http://ordway.umt.edu/SA/VPSA/index.cfm/name/StudentConductCodeDropping the course or changing grading status must strictly follow University policies andprocedures described in the UM catalogue. NOTE: Students cannot change to AUDIT after the 15th day of instruction. Also, after the 30th day of the semester, dropping the course or changing grading status to CR/NCR IS NOT automatically approved. Such changes can be requested by petition, but the petition must be accompanied by documentation of extenuating circumstances. Requests to drop the course or to change grading status simply to benefit a student's grade pointaverage will not be approved.Student Behavior To maximize your likelihood of success, you should attend each lecture, and complete assigned readings before class. Do not simply rely on PowerPoint presentations posted on-line. When in class students are expected to behave with respect towards others. Cell phones,iPods and other electronic devices must be turned off during lecture sessions as well as during exams. Written assignments are due at the start of class on the date indicated on the courseSyllabus, unless otherwise noted. GRADES and AssignmentsMake-up exams will only be administered if arrangements are made prior to the exam. Studentsmust provide documentation of the nature of the emergency or illness. Students who need to arrange a make-up exam because they will be off campus participating in University-relatedactivities (track, ROTC, etc.) must contact Prof. Rosenzweig at least one week prior to theexam, and provide documentation of the activity. Problem sets and essays will only be accepted late if documentation is provided of an illness or traveling difficulty.2                                                                                                                                Grades will be based how many of 600 points you earn over the course of the semester:(1) Two mid-term exams (100 pts each; 200 pts total)(2) Problem sets (100 pts). Two problem sets worth 50 pts each will be assigned in mid-February and in mid-March.  You will have one week to complete each of these/(3) Two essays (50 pts each; 100 points total). Take home questions will be in a short essayformat. You will answer the assigned question and defend your position in a 350-400 word persuasive essay. To support your position, you must provide a minimum of 4 references in a separate bibliography, and cite according to ASM style conventionsdescribed at http://jb.asm.org/site/misc/journal-ita_org.xhtml#top(4) Comprehensive Final Exam (200 pts). 50% of the Final Exam will focus on materialcovered in the last third of the course, the other 50% will focus on material covered in thefirst two-thirds of the class.Consistent with most other DBS classes, the top 10- to 20 %-tile of students can expect to earn a grade of A or A–. The median score of the class will approximately define the partition between grades of B and C. A total score of 359 points (59.9%) or less will be failing (grade of F). Pluses(+) and minuses (–) will be used (A, A–, B+, B, B-, C+, C, C–, D+, D, and D–).3 BIOB 375 General Genetics  Spring 2015  Day/Date   Topic and Lecturer (Rosenzweig unless noted as G=Guest)     Reading      Homework  M  Jan 26 Introduction, Course logistics and a few words about DNA   Ch. 1, pp. 278-285, 325-328 W   Jan 28 Review 1: Mapping the route from genotype to phenotype   Ch. 1, pp. 411-415 F Jan 30 Review 2: Transmission genetics   Ch. 3    M  Feb 2  Review 3: Chromosome basis of inheritance (G)   Ch. 2 W   Feb 4  Chromosome behavior (Sex determination & sex-linkage)  Ch. 4   F Feb 6  Departures from Mendelian ratios (beyond BIOB272) Ch. 5   M Feb 9  Segregation of alleles, recombination and linkage  Ch. 7    W Feb 11 Variation in recombination rate within and between genomes  Ch. 7 & Suppl. Reading  F Feb 13 DNA structure & replication   Ch. 10 & Ch. 12        M Feb 16 PRESIDENT’S DAY – NO CLASS   PSet #1  W Feb 18 DNA replication & repair (G)  Ch. 10 & Ch. 12    F Feb 20 Gene mutations I   Ch. 18    M Feb 23 Gene mutations II (molecular changes)  Ch. 18   PSet #1 due W Feb 25 Gene mutations III (Transposable elements, Tri Repeats) (G)  Ch. 18   F Feb 27 EXAM 1 through Feb 25      [12 lectures]  M Mar 2 Large-scale changes in genome structure  Ch. 8 & Suppl. Reading W Mar 4 Eukaryotic gene structure & expression I  Ch. 14 & Ch. 17   F Mar 6 Eukaryotic gene structure & expression II  Ch. 14 & Ch. 17   M Mar 9 Genomics & Proteomics: Detecting changes (G)  Ch. 20 & pp. 555-562  W Mar 11 Principles of genomic analysis I. Metagenomics (G)  Suppl. Reading   F Mar 13 Principles of genomic analysis II. Phylogenomics (G)  Ch. 20, 26.1 & 26.4  M Mar 16 New tools for genetic & genomic analysis  Ch. 19   PSet #2 W Mar 18 Regulation of gene expression (alternative splicing, RNAi)   Ch. 14 & Ch.17  F Mar 20 Epigenetic regulation of gene expression I  Ch. 21  M Mar 23 Epigenetic regulation of gene expression II  Ch. 21   PSet #2 due W Mar 25 OPEN     F Mar 27 EXAM 2 through Mar 25    [11 lectures]         SPRING BREAK March 30 through April 3  M  April 6  Molecular genetics of epistasis & pleiotropy  Ch. 5 &  Suppl. Reading Essay #1 W April 8 Quantitative inheritance & the analysis of quantitative traits   Ch. 24 & Suppl. Reading  F  April 10 Genetic testing & counseling  Ch. 6    M April 13 Genetics & Evolutionary Medicine (G)  Suppl. Reading  Essay #1 due W April 15 Model genetic systems. I. Yeast & regulation of the cell cycle  Ch. 23 & A12  F  April 17 Cancer genetics  Ch. 23    M April 20 Model genetic systems. II. Drosophila  Ch. 22 (p. 636-643) & A2   W April 22 Model genetic systems. II. Drosophila  (Forward Genetics)  F  April 24 Model genetic systems. III. C. elegans  (G) Suppl. Reading & A6 Essay #2 M April 27 The genetics of Apoptosis   Ch. 22 W April 29 The genetics of Aging  pp. 316-317, 344-346 & Suppl. Reading       F May 1 The genetics of Macroevolution: Hopeful monsters & speciation genes (G)          Essay #2 due  M May 4 Graduate Student presentations (A Gallagher & A Andis)  Suppl. Reading  W  May 6 OPEN   F May  8 Student evaluations and review    T May 12   Comprehensive FINAL EXAM    10:10 – 12:10  NOTE: The BIOB 375 lecture schedule is subject to change. Certain topics may warrant extended classroom discussion or breakthroughs may occur in genetics and evolution that merit our attention.  BIO375 Guest Lecturers: Sarah Certel, Vaughn Cooper, Lila Fishman, Matt Herron, John McCutcheon, Scott Miller, Margie Kinnersley, Eugene Kroll, Katja Voronina 

BIOB 375.01: General Genetics

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BIOB 375.01: General Genetics

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