Abdallah, M.A.E.

Harrad, S.

English

Fourteen tri-deca polybrominated diphenyl ethers (PBDEs) were investigated in 35 human milk samples from Birmingham, UK. While none of the hepta-nona BDEs (the main components of the octaBDE technical mixture) was above the limit of quantitation (LOQ); BDE-47 (average concentration=3.3ngg lipid weight (lw)) was quantified in all samples contributing 34-74% to σtri-hexa BDEs (the principal constituents of the pentaBDE commercial formulation). BDE-209 (the main congener in the decaBDE formulation) was present above the LOQ in 69% of samples (average concentration=0.31ngg lw). Concentrations of σtri-hexa BDEs ranged from 0.2 to 26ngg lw with concentrations of BDE-47&gt;BDE-153&gt;BDE-99. While concentrations of σtri-hexa BDEs in this study (average=5.95ngg lw) were at the high end of those reported from other European countries, concentrations of BDE-209 were lower than those reported in human milk from other countries. The average exposure of a UK nursing infant to σtri-hexa BDEs (35ng (kg bw)day) via breast milk exceeded the upper-bound dietary intakes of both UK adults and toddlers. Using a simple one compartment pharmacokinetic model, PBDE intakes of UK adults via inhalation, diet and dust ingestion were converted to predicted body burdens. Predictions compared well with those observed for σtri-hexa BDEs and BDE-209 in breast milk

University of Birmingham Research Portal

Polybrominated diphenyl ethers in UK human milk:Implications for infant exposure and relationship to external exposure

Mohamed Abou-Elwafa Abdallah

Stuart Harrad

Crossref

Environment International

Polybrominated diphenyl ethers in UK human milk: Implications for infant exposure and relationship to external exposure

http://pure-oai.bham.ac.uk/ws/files/21859041/Polybrominated_diphenyl_ethers_in_UK_human_milk_R1_NCM_1.pdf

Polybrominated diphenyl ethers in UK human milk:Implications for infant exposure and relationship to external exposure

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University of Birmingham Research Portal

University of Birmingham Research Portal

Crossref