Scheltens, P. [Promotor]Barkhof, F. [Promotor]Flier, W.M. van der [Copromotor

Goos, J.D.C.

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Microbleeds in Dementia

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VU Research PortalMicrobleeds in DementiaGoos, J.D.C.2013document versionPublisher's PDF, also known as Version of recordLink to publication in VU Research Portalcitation for published version (APA)Goos, J. D. C. (2013). Microbleeds in Dementia.General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright ownersand it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.            • Users may download and print one copy of any publication from the public portal for the purpose of private study or research.            • You may not further distribute the material or use it for any profit-making activity or commercial gain            • You may freely distribute the URL identifying the publication in the public portal ?Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.E-mail address:vuresearchportal.ub@vu.nlDownload date: 21. May. 2021Jeroen Goos - MICROBLEEDS IN DEMENTIA: CONNECTING THE DOTS MICROBLEEDS IN DEMENTIA:CONNECTING THE DOTSMICROBLEEDS IN DEMENTIA: CONNECTING THE DOTSJeroen GoosUITNODIGINGVoor het bijwonen van de  openbare verdediging van  het proefschrift:MICROBLEEDS IN DEMENTIAdoor:Jeroen Dirk Cornelis Goosom 13.45 uur in de aula  van de universiteit,De Boelelaan 1105Receptie na afloopJeroen GoosVrolikstraat 262-huis1092 TX Amsterdamj.goos@vumc.nlParanimfen:Pieter SluisPicobar@yahoo.comRik Ossenkoppeler.ossenkoppele@vumc.nlOP WOENSDAG 06 FEBRUARI 2013 

English

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CONTENTS
Chapter 1  General introduction    
  
 1.1 Introduction and outline of thesis 
 1.2 Dementia in 2011: Microbleeds in dementia 
  --singing a different ARIA 
Chapter 2 I Clinical associations of Microbleeds in memory  
 clinic patients
 2.1 Alzheimer disease patients with multiple  
  microbleeds; relation with CSF biomarkers  
  and cognition 
 2.2 Microbleeds do not affect rate of cognitive  
  decline in Alzheimer disease 
 2.3 The Incidence of Cerebral Microbleeds:  
  a longitudinal study in a memory clinic  
  population 
Chapter 3 II Underlying and associated pathology of   
 microbleeds in dementia
 3.1 Microbleeds relate to altered amyloid-beta  
  metabolism in Alzheimer disease 
 3.2 No evidence for additional BBB  
  P-glycoprotein dysfunction in AD patients  
  with microbleeds 
 3.3 Dementia with microbleeds and transient  
  neurological episodes: a case report of  
  capillary CAA 
008
009
017
024
025
046
065
086
087
108
119
Microbleeds in Dementia:
Connecting the dots
132
133
154
169
184
204
209
214
216
218
Chapter 4 III Developments in imaging signs of   
 microangiopathy 
 4.1  Susceptibility-Weighted Imaging versus  
  T2*-Weighted Gradient Echo MRI: clinical  
  relevance of improved microbleed detection  
  in memory clinic patients? 
 4.2 Microbleeds in Alzheimer disease using 7T  
  imaging; approaching the true number? 
 4.3 Microinfarcts assessed by post-mortem  
  quantitative T1 relaxation time at 1.5 Tesla in  
  Alzheimer and non-Alzheimer disease  
  cases  
Chapter 5 General discussion, conclusions and future  
 directions
Appendices  Nederlandse samenvatting
  Dankwoord  
  Proefschriften Alzheimercentrum 
  List of publications
  About the author


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Microbleeds in Dementia

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