Abu-Reesh, Ibrahim

Abu-Sharkh, Basel

King Fahd University of Petroleum and Minerals

Comparison of Axial Dispersion and Tanks-in-Series Models for Simulating the 
Performance of Enzyme Reactors.       
 
Abu-Reesh, Ibrahim M.; Abu-Sharkh, Basel F.     
 
Chemical Engineering Department,  King Fahd University of Petroleum Minerals,  Dhahran,  
Saudi Arabia.     
 
Industrial & Engineering Chemistry Research  (2003),  42(22),  5495-5505.   
 
 
Abstract 
 
A comparison of two modeling approaches for simulating the performance of enzyme reactors 
using the axial dispersion and tanks-in-series models is described.  The two modeling 
approaches are compared for the steady-state performance of enzyme reactors assuming 
Michaelis-Menten kinetics with competitive product inhibition.  The performance of the reactors is 
described in terms of substrate conversion and yield.  The equation Pe = 2(N - 1) is used to 
correlate the parameter of the dispersion model (Pe) with that of the tanks-in-series model (N) for 
the entire range of dispersion from plug flow to CSTR.  The predictions of the two models agree 
well, esp. at low dimensionless residence times and high Peclet nos.  Practically, the predictions 
of the two models are essentially equiv. when the above equation is used to relate their two 
parameters. However, the tanks-in-series model is simpler and has computational advantages 
over the dispersion model, although its phys. basis is not as clear as that of the dispersion model.  
Lactose hydrolysis by the enzyme β-galactosidase, which exhibits Michaelis-Menten kinetics with 
competitive product inhibition, is used as a model system in this study.  The kinetic parameters 
for lactose hydrolysis are obtained from the literature. 
 


Comparison of Axial Dispersion and Tanks-in-Series Models for Simulating the Performance of Enzyme Reactors

https://eprints.kfupm.edu.sa/id/eprint/9217/1/Comparison_of_Axial_Dispersion_and_Tanks_in_Series_Models_for_Simulating_the_Performance_of_Enzyme_Reactors.pdf

Comparison of Axial Dispersion and Tanks-in-Series Models for Simulating the Performance of Enzyme Reactors

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King Fahd University of Petroleum and Minerals