Adeyinka, Ikeade

Fukushi, Minori

Jabban, Leen

Koh, Ryan

Metcalfe, Benjamin

Zariffa, Jose

English

OPUS

A comparison of selective recording approaches in the peripheral nervous system using extraneural electrodes

        Citation for published version:Koh, R, Jabban, L, Fukushi, M, Adeyinka, I, Zariffa, J & Metcalfe, B 2022, 'A comparison of selective recordingapproaches in the peripheral nervous system using extraneural electrodes', Toronto Biomedical EngineeringConference 2022, 15/06/22.Publication date:2022Document VersionEarly version, also known as pre-printLink to publicationUniversity of BathAlternative formatsIf you require this document in an alternative format, please contact:openaccess@bath.ac.ukGeneral rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright ownersand it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.Download date: 08. Jun. 2022A comparison of selective recording approaches in the peripheral nervous system using extraneural electrodes  Ryan G. L. Koh, Leen Jabban, Minori Fukushi, Ikeade C. Adeyinka, José Zariffa and Benjamin Metcalfe  ToBE’s requirements (550 characters with spaces – Objective, 720 characters with spaces – Methods, 720 characters with spaces – Results, 370 characters – Conclusions & Significance  Objective: The peripheral nervous system (PNS) is a key target for developing neural interfaces but recording from the PNS is challenging. Nerve cuffs are frequently used providing a single recording point but advances in manufacturing technology have enabled multi-contact nerve cuffs that can collect temporal and spatial information more effectively. Selective techniques have been developed with different time resolutions but it is unclear how the number of contacts and their configuration affects performance.   Approach: This study investigates 2 extraneural recording techniques and compares them using peripheral nerve recordings from the sciatic nerve from 3 datasets: a high density (HD, 56-contact, 2.3 cm length), reduced-HD (16-contact, 1.3 cm length) and low density (LD, 16-contact, 4.25 mm length). Different types of activity were selectively evoked in the rats (HD / reduced-HD: dorsiflexion, plantarflexion, and pricking of the heel; LD: proprioception, nociception, and touch). Two techniques in the literature (linear discriminant analysis (LDA) and spatiotemporal signatures) were applied to these recordings and the performance of these techniques were evaluated using classification accuracy and F1-score.   Results: Both techniques showed an expected improvement in classification accuracy with the spatiotemporal signature approach showing an improvement of 21.6 (LD to HD) – 24.6% (reduced-HD to HD) and the LDA approach showing an improvement of 2.9 (reduced-HD to HD) – 41.3% (LD to HD). The results for both techniques were also comparable in both the LD and HD dataset. The results show that the spatiotemporal signature approach could be used in a more compact space and that the addition of electrode contacts greatly affects performance. A similar trend can be observed with the LDA approach with the large increase in performance likely due to the increase in electrode spacing.    Significance: This study provides a direct comparison between 2 techniques discussed in the literature and shows the changes in performance of these techniques with different number of electrode contacts and configuration. It will aid in the development of more selective peripheral nerve interfaces for use in neuromodulation and neuroprosthetic applications.    Ryan GL Koh 1, Leen Jabban 2, Minori Fukushi 1, Ikeade C Adeyinka 1, José Zariffa 1 3, Benjamin Metcalfe 2 1. KITE – Toronto Rehabilitation Institute – University Health Network, Toronto, Canada, 2. Centre for Biosensors, Bioelectronics, and Biodevices (C3Bio), Department of Electronic and Electrical Engineering, University of Bath, Bath, UK, 3. Institute of Biomedical engineering, University of Toronto, Toronto, Canada     

https://purehost.bath.ac.uk/ws/files/233557805/ToBE_Abstract_2022.pdf

A comparison of selective recording approaches in the peripheral nervous system using extraneural electrodes

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