A Ibarra

A Sala

C Dupon

EL Berdan

GS Cabana

J Yoo

JC Pinto

K Sandoval

LC Tsoi

MK Kuhner

MP Simmons

R Pereira

R Zhou

RE Mills

RL Resque

SJ Ingley

ST Kalinowski

YG Yao

YS Peixouto

Z Zhang

ZA Szpiech

Scientific Reports

AbstractAs a multi-ethnic country, China has some indigenous population groups which vary in culture and social customs, perhaps as a result of geographic isolation and different traditions. However, upon close interactions and intermarriage, admixture of different gene pools among these ethnic groups may occur. In order to gain more insight on the genetic background of X-Chromosome from these ethnic groups, a set of X-markers (18 X-STRs and 16 X-Indels) was genotyped in 5 main ethnic groups of China (HAN, HUI, Uygur, Mongolian, Tibetan). Twenty-three private alleles were detected in HAN, Uygur, Tibetan and Mongolian. Significant differences (p &lt; 0.0001) were all observed for the 3 parameters of heterozygosity (Ho, He and UHe) among the 5 ethnic groups. Highest values of Nei genetic distance were always observed at HUI-Uygur pairwise when analyzed with X-STRs or X-Indels separately and combined. Phylogenetic tree and PCA analyses revealed a clear pattern of population differentiation of HUI and Uygur. However, the HAN, Tibetan and Mongolian ethnic groups were closely clustered. Eighteen X-Indels exhibited in general congruent phylogenetic signal and similar cluster among the 5 ethnic groups compared with 16 X-STRs. Aforementioned results proved the genetic polymorphism and potential of the 34 X-markers in the 5 ethnic groups.</jats:p

Suhua Zhang

Yingnan Bian

Li Li

Kuan Sun

Zheng wang

Qi Zhao

Lagabaiyila Zha

Jifeng Cai

Yuzhen Gao

Chaoneng Ji

Chengtao Li

Crossref

Population genetic study of 34 X-Chromosome markers in 5 main ethnic groups of China

Population genetic study of 34 X-Chromosome markers in 5 main ethnic groups of China

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