A. I. Kuraishy

A. Shabaik

A. Strasner

C. Ramirez-Sanchez

M. Ammirante

M. Karin

S. Shalapour

W. Zhang

Androgen-deprived prostate cancer (PCa) is infiltrated by B lymphocytes that produce cytokines that activate IκB kinase α (IKKα) to accelerate the emergence of castration-resistant tumors. We now demonstrate that infiltrating B lymphocytes and IKKα are also required for androgen-dependent expansion of epithelial progenitors responsible for prostate regeneration. In these cells and in PCa cells, IKKα phosphorylates transcription factor E2F1 on a site that promotes its nuclear translocation, association with the coactivator CBP, and recruitment to critical genomic targets that include Bmi1, a key regulator of normal and cancerous prostate stem cell renewal. The IKKα–BMI1 pathway is also activated in human PCa.</jats:p

Massimo Ammirante

Ali I. Kuraishy

Shabnam Shalapour

Amy Strasner

Claudia Ramirez-Sanchez

Weizhou Zhang

Ahmed Shabaik

Michael Karin

Crossref

Genes & Development

An IKKα–E2F1–BMI1 cascade activated by infiltrating B cells controls prostate regeneration and tumor recurrence

An IKK -E2F1-BMI1 cascade activated by infiltrating B cells controls prostate regeneration and tumor recurrence

An IKK -E2F1-BMI1 cascade activated by infiltrating B cells controls prostate regeneration and tumor recurrence

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