AK Kim

B Amann

C Botti

CM Botham

DI Kim

E Tateishi-Yuyama

KA Giles

KB Lee

KI Paraskevas

L Norgren

M Teraa

MD Iafrati

PF Klein-Weigel

PP Huang

RB Rutherford

S Durdu

S Matoba

S Shionoya

V Motukuru

V Prochazka

Scientific Reports

AbstractOur goal was to evaluate early results of the clinical application of autologous whole bone marrow stem cell transplantation (AWBMSCT) for critical limb ischemia (CLI) in patients with Buerger’s disease. We retrospectively analyzed the data of 58 limbs of 37 patients (mean age, 43.0 years; range, 28–63 years; male, 91.9%) with Buerger’s disease with CLI who were treated with AWBMSCT from March 2013 to December 2014. We analyzed Rutherford category, pain score, pain-free walking time (PFWT), total walking time (TWT), ankle brachial pressure index (ABPI) and toe brachial pressure index (TBPI) and investigated wound healing and occurrence of unplanned amputations. The mean follow-up duration was 11.9 ± 7.2 months (range, 0.9–23.9 months) and 100%, 72.4% and 74.1% of patients were available to follow-up 1, 3 and 6 months after AWBMST, respectively. At 6 months, patients demonstrated significant improvements in Rutherford category (P &lt; 0.0001), pain score (P &lt; 0.0001), PFWT (P &lt; 0.0001) and TBPI (P &lt; 0.0001). ABPI was increased compared to baseline, but the difference was not significant. A total of 76.5% ischemic wounds achieved complete or improved healing. AWBMSCT is a safe and effective alternative or adjunctive treatment modality to achieve clinical improvement in patients with CLI.</jats:p

Seon-Hee Heo

Yoong-Seok Park

Eun-Suk Kang

Kwang-Bo Park

Young-Soo Do

Kyung-Sun Kang

Dong-Ik Kim

Crossref

Early Results of Clinical Application of Autologous Whole Bone Marrow Stem Cell Transplantation for Critical Limb Ischemia with Buerger’s Disease

Early Results of Clinical Application of Autologous Whole Bone Marrow Stem Cell Transplantation for Critical Limb Ischemia with Buerger’s Disease

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