Erin E. Berlew

Gergana A. Vandova

Louise K. Charkoudian

Maureen E. Hillenmeyer

Significance
          Type II polyketide natural products are powerful antimicrobial agents that are biosynthesized within bacteria by enzyme-encoding clusters of genes. We present a method to elucidate the evolution of these gene clusters as a whole, illuminating how natural selection has led to the chemical diversity of type II polyketides. Our approach can be applied to understand how other natural product gene clusters evolve. This understanding may aid efforts to access novel natural products and to design rational enzyme assemblies that produce chemicals of desired structures and activities.</jats:p

Evolution of chemical diversity by coordinated gene swaps in type II polyketide gene clusters

Abstract

Similar works

Full text

Available Versions

Crossref