Alina Codita

Andrij Cherninsky

Ayllon

Chapman

Chiara Tesoriero

Gigliola Grassi-Zucconi

Giuseppe Bertini

Håkan Karlsson

Karl Ljungberg

Krister Kristensson

Marina Bentivoglio

Ming-Dong Zhang

Peter Liljeström

Scammell

Tibor Harkany

Tomas G. M. Hökfelt

Significance
          Influenza A virus infections are risk factors for narcolepsy, a disease in which autoimmunity has been implicated. We tested experimentally whether influenza virus infections could be causally related to narcolepsy. We found that mice infected with a H1N1 influenza A virus strain developed over time sleep–wake changes described in murine models of narcolepsy and narcolepsy patients. In the brain, the virus infected orexin/hypocretin-producing neurons, which are destroyed in human narcolepsy, and other cells in the distributed sleep–wake-regulating neuronal network. The findings, obtained in mice lacking an adaptive autoimmune response, thus provide new avenues for research on infection-related mechanisms in narcolepsy.</jats:p

Crossref

Proceedings of the National Academy of Sciences

H1N1 influenza virus induces narcolepsy-like sleep disruption and targets sleep–wake regulatory neurons in mice

H1N1 influenza virus induces narcolepsy-like sleep disruption and targets sleep–wake regulatory neurons in mice

Abstract

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