Dejana E

R Loch Macdonald

Shahram Eisa-Beygi

Stainier DY

Xiao-Yan Wen

 The endothelial-specific transmembrane glycoprotein, vascular endothelial (VE)-cadherin, is required for the organization of a stable vascular endothelium. A number of cerebrovascular disorders are associated with mutations in genes that otherwise regulate vascular integrity through VE-cadherin dynamics. Hence, identification and characterization of regulatory pathways contributing to endothelial cell-cell adhesion is of clinical relevance, particularly in the treatment of aneurysms and cerebral cavernous malformations. The zebrafish ( Danio rerio) have recently emerged as a powerful paradigm for studies geared toward elucidating the etiology of cerebrovascular disorders, principally in uncovering the genetic and mechanistic basis controlling endothelial adhesive barrier function. </jats:p

Regulatory Pathways Affecting Vascular Stabilization via VE-Cadherin Dynamics: Insights from Zebrafish ( Danio Rerio

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